The reaction mechanism of isobutyl chloroformate and carboxylic acid is that mixed acid will be generated after the reaction, and then react with amine to obtain the corresponding amide. According to public information, isobutyl chloroformate is an amide coupling agent commonly used in large-scale production. This reagent is cheap, and the mixed anhydride formed with carboxylic acid shows high selectivity in the reaction with amine, and the by-products are isobutanol and carbon dioxide. Isobutyl chloroformate is an important chemical raw material, which is often used in organic synthesis and drug synthesis.