308 excimer laser is a commonly used device to treat vitiligo at present. It has a good therapeutic effect, but it should also pay attention to some shortcomings in clinical application. First, the energy of 308 laser in the treatment of advanced vitiligo should not be too large, because transient erythema and blisters will appear in some places after laser treatment.

After the blister occurs, it means that there is trauma on the skin. In the late stage, trauma will induce isomorphic reaction, that is, vitiligo will enlarge its area and worsen its condition.

Second, in the long-term stable period of vitiligo treatment, if the number of treatments exceeds 50 times, it will lead to the thickening of the stratum corneum of the skin, so it is difficult for 08 laser to break through the stratum corneum and cause certain obstacles to the absorption of the skin, which is called the platform period of 308 laser treatment.

After the plateau period, the therapeutic effect will be affected. At this time, it is often to stop treatment for a period of time or use urea ointment and salicylic acid ointment to achieve the purpose of dissolving and moisturizing, so that after the stratum corneum becomes thinner, the normal stratum corneum is treated with 308 laser.