Theophylline is a raw material medicine, which belongs to medicine. You must obtain a Drug Business License before you can operate. Those who operate without a license and are suspected of committing a crime shall be punished for illegal operation.

The crime of illegal business operation, according to the provisions of Article 225 of the Criminal Law of People's Republic of China (PRC), refers to the crime of committing one of the following illegal business operations in violation of state regulations:

(a) without permission, dealing in franchise, monopoly goods or other commodities with restricted trading as stipulated by laws and administrative regulations;

(2) buying and selling import and export licenses, import and export certificates of origin and other business licenses or approval documents stipulated by laws and administrative regulations;

(three) without the approval of the relevant competent departments of the state, illegally engaged in securities, futures, insurance business or illegally engaged in fund settlement business;

(four) engaged in other illegal business activities, disrupting the market order, and the circumstances are serious.

Theophylline can reduce the tension of smooth muscle and dilate respiratory tract. It can promote the release of endogenous epinephrine and norepinephrine and relax airway smooth muscle; Inhibit smooth muscle endoplasmic reticulum from releasing calcium ion, reduce intracellular calcium ion concentration, and produce airway dilatation. Theophylline has a strong relaxing effect on smooth muscle, but it is not as good as β receptor agonist.

On October 27th, 2065438+071KLOC-0, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization was preliminarily sorted out for reference. Theophylline is in the list of three carcinogens.

1. Used for bronchial asthma, acute bronchitis, asthmatic bronchitis, obstructive emphysema, etc. Relieve wheezing symptoms. It is also suitable for bronchospasm with symptoms of chronic bronchitis and emphysema.

2. It can be used for patients with cardiogenic asthma, cardiogenic edema and acute cardiac insufficiency.

3. It can also be used for patients with biliary colic.

1. Oral administration can cause heartburn, nausea, vomiting, arrhythmia, loss of appetite, abdominal distension and elevated blood uric acid. Long-term use can cause headache, insomnia and palpitation.

2. Local irritation is great, intramuscular injection can cause local pain, redness and swelling, and dose treatment can cause insomnia or anxiety.

This product should be taken after meals to reduce gastrointestinal irritation; Smoking, chronic alcoholism and inducing liver drug enzymes can reduce the plasma concentration of theophylline, so it is necessary to increase the dose of theophylline appropriately. Theophylline drugs can cause arrhythmia and aggravate the original arrhythmia. Pay close attention to any changes in the patient's heart rate or rhythm. When theophylline drugs are injected intravenously too fast or the plasma concentration of theophylline is higher than 20μg/ml, toxic reactions may occur, such as arrhythmia, increased heart rate, muscle tremor, epilepsy, transient hypotension or peripheral circulation failure. When theophylline concentration is higher than 40μg/ml, fever, dehydration and convulsion will occur. It may happen, and in severe cases, breathing and heartbeat may stop and die. Taking sedatives in advance can effectively prevent it.