1, the role of mast cells in rheumatoid arthritis

The role of mast cells in the secretion and regulation of cathepsin and matrix metalloproteinase and its relationship with cartilage and bone destruction have not been reported. In this study, the effects of mast cells on the secretion and expression of cathepsins G, C, K and S, as well as the destruction of cartilage and bone in RA were demonstrated by in vivo and in vitro experiments of Kit W-sh/W-sh mouse model.

2. The role of cathepsin in rheumatoid arthritis.

Academic position: Member of Rheumatology Branch of Chinese Medical Doctor Association, Member of Osteoporosis Professional Committee of China Geriatrics Association.

Research topic:

1, Effect of mast cells in RA on cathepsin expression of fibroblasts 2009-20 1 1 Guangdong Natural Science Foundation and Baiyun District Science and Technology Plan Project 50,000+50,000.

2. Effect of synovial mast cells on cathepsin and MMPs in fibroblasts: "A new target for the treatment of rheumatoid arthritis" 20 10-20 12 National Natural Science Foundation of China 300,000 yuan.

3. The role of 3.MCs in the expression of cathepsin and MMP in RA bone destruction 20 10-20 12 The Dean's Fund is 30,000 yuan. Total disposable funds at present: 430,000.