2. What are the preliminary experimental results directly related to the design of this project? You don't need to list all your contents regardless of weight. Instead, we need to have a certain targeted tendency towards the subject direction, focusing on the content related to the subject direction. If there are hard data results, be sure to attach them, and it is best to bring the result chart, especially the highly innovative links. However, you must carefully select the amount of data in the pre-experiment. If you put too much, the jury will think that your work has been done almost, and there is no need to apply for funds.
It is the facade of a tender and the key to get a good impression from the evaluation. Whether it's judging funds or papers, you can have a preliminary impression after reading the title and abstract. Continue to read the following content, often in order to strengthen the judgment of reviewers. If the topic is good and the abstract is clear, the reviewer can easily understand what problem to solve, how to solve it, and the significance of studying the problem, so he can't refuse.
It is a great test for a person's logical thinking and writing ability, because the abstract has a limit of 400 words (including punctuation marks), so how to "tell" a story well in a limited space is a problem worth pondering. Writing generally follows six steps:
(Six steps of summary)
Mechanism of CCN 1 (rich in cysteine 6 1) in promoting sarcopenia and uremia in the elderly.
Research background and progress: sarcopenia in the elderly is a new geriatric disease, and the incidence rate in China is 12.3% for males and 4.8% for females. Uremic sarcopenia has not been paid attention to.
Problems to be solved: sarcopenia will increase mortality, the pathogenesis is unclear, the diagnostic criteria in Asia and Europe are not uniform, and the curative effect is poor.
Research basis: We found that CCN 1 (rich in cysteine 6 1) can cause sarcopenia;
Scientific hypotheses were put forward: ①CCN 1 induced the aging of muscle satellite cells (MSC) and induced the progenitor cells of fiber/adipocytes (FAP) to generate adipocytes; ② Inhibition of CCN 1 and prevention of muscle aging can improve sarcopenia in the elderly; ③ Integrin is the receptor of CCN 1, and CCN 1 combines with different integrins to play different roles. The function of integrin in muscle is not clear. None of these three viewpoints has been reported.
Further research is needed: ① To study the effects of CCN 1 on skeletal muscle aging, adipocytes and myocytes through CCN 1 knockout and CCN 1 overexpression, 5/6 nephrectomy mouse model, MSC and FAP cell culture, sarcopenia and uremic sarcopenia elderly patients; ② the relationship between CCN1and Wnt-3a; ③ The binding site of CCN1and integrin.
Research significance: strong innovation, exploration value and clinical significance.
The research goal is to solve scientific, academic or technical problems through this project. That is to say, tell the judges why this research should be carried out, what results can be achieved and what problems can be solved by completing this research.
The writing of research objectives can correspond to the research content and should follow the following principles: ① highlight key issues and reflect research difficulties; (2) Corresponding to the research content, avoiding repeated words; ③ Be clear, novel, concise and concise (1-2 sentence overview).
Confirm/verify/clarify the role/existence/expression/function of xx in xx.
Reveal/discuss/study the relevant mechanism of xx regulating/promoting/inhibiting xx through xx.
It is clear that xx has an important therapeutic effect on xx, which may become one of the potential targets of xx disease/has important clinical significance or application value/predicts the prognosis of xx disease.
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Text | Coconut?