2. Study on pharmacodynamics and mechanism of traditional Chinese medicine.
3. Safety evaluation of new drugs 1. National Natural Foundation of China (30973602): Screening of specific molecular markers for evaluating reproductive toxicity of growth factor drugs in mouse embryonic stem cells (presiding)
2. National Key Project of the Ministry of Science and Technology (2009ZX09 103-749): Study on a series of modifiers of recombinant human acidic fibroblast growth factor (deputy director), a candidate drug for treating Alzheimer's disease.
3. Guangzhou Science and Technology Project (2010y1-c851): Screening specific molecular markers of mouse embryonic stem cells to evaluate the reproductive development toxicity of growth factor drugs (presiding).
4. Guangdong Science and Technology Project (2011B031700009): Establishment of mouse embryonic stem cell experimental model for evaluating the developmental toxicity of common Chinese medicines during pregnancy (presiding).
5. Guangdong Natural Science Foundation Project (S 20 11KLOC-0/001898): Establishment (hosting)1EST model of mice for evaluating developmental toxicity of commonly used Chinese medicines during pregnancy. "Application and Development of Recombinant Basic Fibroblast Growth Factor" won the first prize of the Ministry of Education.
2. "Development and application of recombinant fibroblast growth factor (rFGF) in vitro in clinic"-the third prize of China Medical Science and Technology Award.
3. Third Prize of Guangdong Science and Technology for "Research on the Regulation and Repair Mechanism of Growth Factors"
4. "Study on Mutants of Human Chemokine Receptor Antagonist-Virus Chemokine vMIP and Human Chemokine SDF- 1SDF- 1α" won the second prize of Guangdong Science and Technology.
5. "Development and application of a new drug recombinant human acidic fibroblast growth factor" (1) First Prize of Guangdong Science and Technology Xu Hua, Zheng Qing, et al. Long-term toxicity study of recombinant human acidic fibroblast growth factor in dermatology. Journal of China Pharmaceutical University, 2002,34 (1): 46-50
2 Xu Hua, Yang Xiaoming. Study on the anti-tumor effect of Ligusticum Chuanxiong alcohol extract on S 180 and H22 mice. Chinese Herbal Medicine, 2003,26 (4): 272-273.
(3) Li Xiaojian, Xu Hua, Zhao Wen, etc. Pharmacokinetics of recombinant human acidic fibroblast growth factor in skin. Journal of Pharmacy, 2002,37 (6): 424-427 (correspondent)
(4) Xu Hua, Wen Jie, Yu Liping, etc. Study on the anti-acute liver injury effect of compound astragalus extract. China Journal of Pathophysiology, 2005,21(2): 304 ~ 307.
Yao, Xu Hua, Zheng Qing, et al. Reproductive toxicity of recombinant human acidic fibroblast growth factor. Journal of China Pharmaceutical University, 2005,3695: 461-463.
Xu Hua, Zheng Qing, Wu Xiaoping et al. Phase I clinical study of recombinant human acidic fibroblast growth factor. China Journal of New Drugs, 2005,14 (12):1476-1479.
7 Xu Hua, Yao, Zheng Qing, et al. Genetic toxicity of recombinant human acidic fibroblast growth factor. Journal of Jinan University (Medical Edition), 2006,27 (4): 536-539.
Hong Xu, Hai Guangfeng, Xiang Jizhong, et al. Protective effect of non-mitogenic human acidic fibroblast growth factor on hepatocyte injury. Liver alcohol research, 2007, 37: 836-844
Hong Xu, Yang Jianning, Li Xinke, et al. Protective effect of acidic fibroblast growth factor on retina after eliminating mitogenic activity. Journal of Ophthalmic Pharmacotherapeutics, 2008,24 (5): 445-451
⑽ Hong Xu, Hai Guangfa, Hong Xu, etc. Protective effect of non-mitogenic human acidic fibroblast growth factor on renal ischemia-reperfusion injury. China Journal of Pathophysiology, 2008,24 (4): 552-557.
⑾ Xu Hua, Yang Jinnan, Zheng Qing, Yao. Protective effect of non-mitotic haFGF on retinal injury induced by MNU in rats. Journal of Pharmacy, 2005,40 (4): 306 ~ 310.
⑿ Hai Guangfan, Xu Hua, Yu Jing, et al. Antagonistic effect of nmhaFGF on hydrogen peroxide-induced apoptosis of NRK52E cells. China Journal of Pathophysiology, 2008,24 (11): 2230-2234 (correspondent).
[13] Hong Xu, Li Xinke, Zheng Qing, etc. Protective effect of acidic fibroblast growth factor mutant on cerebral ischemia-reperfusion injury in rats. Injury, 2009,40 (7): 963-967
[14] Xu Hua, Huang Yadong, et al. Protective effect of nmhaFGF on myocardial ischemia-reperfusion injury in rats. Journal of China Pharmaceutical University, 2009,40 (2):161-165.
⒂ Yu Jing, Xu Hua, Yao, etc. Effects of recombinant human fibroblast growth factor on the expression of c-fos, c-jun and c-myb mRNA in sertoli cells of rats. Journal of Toxicology, 20 10/0,24 (1):114-.
Hong Xu, Wen Yuping, zhaowei, et al. Antitumor activity of sesame flower extract in vitro. Journal of Pharmaceutical Research, 20 10/0,9 (5): 455-462.
⒄ Xu Hua, Jason, Yu Jing. Study on epilepsy induced by synthetic kainic acid in rats. China Journal of Pathophysiology, 20 1 1, 27 (1): 204-208.
⒅ Xu Hua, Deng, He Qing, et al. Preliminary evaluation of developmental toxicity of basic fibroblast growth factor by embryonic stem cell test model. Bulletin of Pharmacology of China, 2012,28 (3): 347-351.
Yang, Xu Hua, Zhang, etc. Pharmacokinetics and blood-brain barrier permeability of fusion protein of human acidic fibroblast growth factor and transmembrane peptide in mice. Acta pharmacy, 20 1 1, 46 (10):1204-65438+.
Xu Hua, Su, Jiang, et al. Effect of acidic fibroblast growth factor compound preservation solution on cryopreservation of rat liver. China Journal of Pathophysiology, 2012,28 (5): 933-936.