subject
Computer Applied Technology
research direction
Complex disease gene linkage mapping method, biomedical informatics, gene chip related informatics technology, pharmacogenomics informatics and systems biology.
On the Achievements of Works
I. Sponsoring and participating in 26 projects:
9 projects under research (2 national natural science funds and 2 863 high-tech projects);
1. National Natural Science Foundation: Pattern Recognition and Feature Extraction Technology for Gene Mapping of Multigene Complex Genetic Diseases (30 1705 15), presided over (first place), 200 1.
2. National Natural Science Foundation of China: Gene recognition data mining technology based on gene expression profile of human complex diseases. Moderator (first place), 2003.
3. National High-tech Research and Development Program (863 Program), Gene Chip Technology Platform for Molecular Mechanism of Chinese Medicine in Cancer Suppression, Deputy Head, 2003.
4. Provincial Science Plan: Bioinformatics comprehensive analysis platform for gene function and drug target discovery, presided over (first place), 2003.
5. Harbin Medical University 2 1 1 Project: Open Bioinformatics Laboratory and Comprehensive Bioinformatics Analysis Platform, presided over (first place)
6. National High-tech Research and Development Program (863 Program), research and development of in-situ synthetic gene chip technology, participation, 2003.
7. Municipal Science Project: Efficient Bioinformatics Analysis Technology for Screening Effective Components of Traditional Chinese Medicine, Presided, 2003.
8. Provincial Department of Education: apply numerical system classification technology to find complex disease genes and participate.
9. Provincial Health Department: Classification technology of human diseases based on neural network and gene chip expression profile.
Project 17 has been completed.
1. National Natural Science Foundation: Methods and Optimization Strategies for Gene Mapping of Complex Diseases (39970397), second place.
2. Provincial Science Plan (tackling key problems) project: Computer method and application of human gene location and identification. Second place.
3. Provincial Natural Science Foundation: Research on gene location technology of multi-gene complex diseases based on artificial neural network. Moderator (first place).
4. Municipal Science Plan (tackling key problems) project: Mathematical computer method and application of gene linkage location analysis. Moderator (first place).
5. Provincial Natural Science Foundation: Methods, procedures and applications of DNA and protein sequence analysis (first place).
6. Provincial Science Plan (tackling key problems) project: Computer method and application of human gene localization and identification, second place.
7. Municipal Science Plan: Mathematical computer method and application of gene linkage analysis, second place, completed.
8. Project of Provincial Education Commission: Computer Analysis System of Human Recombinant Inbred Lines and Family Data, the second prize, has been completed.
9. Subject of Provincial Health Department: Automated Pharmacokinetic Analysis Software Package, presided over (first place), has been completed.
10. Youth project of provincial science and technology commission: quantitative research on drugs for treating cysticercosis and design of optimal individual administration scheme, the moderator (first place) has been completed.
1 1. Project of Provincial Family Planning Commission: Computer-aided diagnosis and inquiry system for prenatal and postnatal care, fourth place, completed.
12. Project of Provincial Education Commission: Development and application research of computer analysis system for enzyme and receptor dynamics, third prize, has been completed.
13. Project of Provincial Administration of Traditional Chinese Medicine: quantitative analysis of B-ultrasound images and its application in TCM syndrome differentiation of liver diseases ranked third, which has been completed.
14. the project of municipal science and technology commission: development of computer processing system for orthopedic special medical images, third prize, has been completed.
15. Project of Provincial Education Commission: Computer analysis of risk estimation of genetic disease recurrence, presided over (first place), has been completed.
16. Subject of Ministry of Aerospace Industry: Study on the Structure of Factor-intensive Industries and the Choice of Development Strategies in China, No.5. ..
17. Subject of Provincial Health Department: Using small family data for gene mapping. Subject of Provincial Health Department: Gene Mapping with Small Family Data, second place.
Second, the main award-winning achievements:
1. The research on pattern recognition method of complex disease gene map won the first prize of natural science in provincial universities and the second prize of natural science in provincial government. 2005 1.
2.PPAP 3.0 computer system for population and family data analysis of human and medical genetics won the first prize of the provincial education commission and the third prize of the provincial government. 1996, third place.
3. The automatic pharmacokinetic analysis system won the second prize of the provincial health department and the fourth prize of the provincial government. 1996,No. 1.
4. The development and application of computer consultation and diagnosis system for genetic eugenics won the first prize of Provincial Family Planning Commission. Excellent medical audio-visual teaching material award of Ministry of Health. 1997, 5th place.
5. The development and application of the dynamic data analysis system of physiological system (drugs, receptors, enzymes and immunity) won the third prize of the Provincial Education Commission, 1998, ranking third.
6. The series research on cysticercosis won the first prize of the Provincial Education Commission and the third prize of the provincial government. 1998, No.65438 +0 1.
7. "Study on China's Production Factor-intensive Industrial Structure and Its Development Strategy Choice" 1993 won the second prize of Scientific and Technological Progress Award from the Ministry of Aerospace Industry. 1993, 5th place.
Iii. Publication of papers (100):
100. Li Xia et al. Gene Mining: A Novel and Effective Set Decision-making Method for Finding Disease Genes Using Microarray Expression Profiles. Nucleic acid research, 2004; 32(9),2685-2694; (Impact factor in 2002: 7.05 1)(SCI)
99. An integrated method of gene discovery based on DNA microarray data. Science in China (Series C) 2004; 34(4).(SCI)
98. Li X, Rao S, Moser KL, Elston RC, Olson, Guo Z, Zhang T: Discriminant analysis of gene mapping of complex discrete human diseases. Natural Science Progress 2002, 12:43 1-437. (SCI)
97. Li X, Rao S, Elston RC, Olson, Mercer KL, Zhang T, Guo Z: Localization of potential genes simulating complex diseases by discriminant analysis. Genetic epidemiology 200 1, 21Suppl1:S 516-521. (SCI)
96. Li Xia, Zhang,, Selection method of integrated characteristic genes based on classification tree, chinese journal of computers, 2004; Article 27, paragraph 5
95. Genetic mapping strategy for taxonomic characters. Genetics, 2000; BG5 1: 1- 15。 (SCI)
94. Multivariate sibling pair linkage analysis of longitudinal phenotype with three stepwise analysis methods, Chinese Journal of Medical Genetics, 2003, 4:S68. (SCI)
93. Rao Sheng, Li Li, Li Xiao, Mo Zeguang, Guo Zhi, Genetic linkage analysis of longitudinal hypertension phenotype with three comprehensive methods, 2002; BMC Genetics 2003 4(Suppl 1):S48(SCI)
92. Rao, Li, Zhang, Guo, Mo, Wang: Mining disease-related genes from gene chip data by integrated decision-making method. Genetic epidemiology 2003, 25:267. (SCI)
9 1. Rao, Li, Zhang Dongwei, Guo, Moser, Wang: An integrated method of gene discovery based on gene chip data. American Journal of Human Genetics 2003, 73:604. (SCI)
90. Li X, Rao S, Moser KL, Elston RC, Olson, Guo Z, Zhang T: Sibling linkage analysis of complex diseases based on pattern recognition. Polygenic diseases and human health —— Proceedings of the International Symposium on Gene Mapping and Identification of Complex Traits. Chansa, China; 2002
89. Li X, Zhang T, Jiang W, Rao S, Li L, Guo Z: Reverse engineering of multiple delay gene regulatory networks. SNPD Beijing.
88. Li, Rao, Alston, Moser, Zhang, Guo: Using discriminant analysis to locate the potential genes of complex diseases. In: Genetic Workshop of International Society of Genetic Epidemiology12; 2000; San Antonio, Texas USA.
87. Li Xia, Zhang, Li Li, Study on the effectiveness of decision tree feature gene selection method, Chinese Journal of Biomedical Engineering; 2004, 23( 1):66-72
86. Li Xia, Zhang, Rao Shaoqi, Li Li, Decision Forest Method for Characteristic Gene Mining, Journal of Harbin Institute of Technology, 2004,36 (4).
85.Rao S, Li X, Guo Z, et al. Variance analysis method of linkage analysis for siblings of human diseases with complex sequence. China Journal of Biomedical Engineering, English Edition 2002,11:3; 104- 1 12
84. Using structural heteroscedasticity threshold model to locate quantitative trait loci of ordinal traits: I. Mathematica Applica, 200 1, 14(3):46-5 1.
83. Using structural heteroscedasticity threshold model to locate quantitative trait loci of ordinal traits: II. Numerical application. Theory. Mathematica Applica，200 1， 14(3):3-9。
82. Zheng Guo, Wang Qi, Huiyu, Li Xia. Accurate classification of cancer types based on decision tree analysis of gene functional expression profile, SNPD, 2004.
8 1. Li Lin, Jiang Wei, Rao Sheng, Guo, Li: Feature gene selection based on hybrid genetic algorithm and support vector machine. SNPD Beijing 2004.
80. Guo Zhi, Li, Rao, Moser, Gong, Shen, Li, Conneta, Qi Zuowei,,, Wang: Discrimination of longitudinal phenotype; Sibling linkage analysis. In: Genetic Workshop of International Society of Genetic Epidemiology13; 2002; New Orleans, Louisiana USA
79.s Rao, L Li, X Li, KL Moser, Z Guo, G Shen, R Cannata, E Zirzow, Q Wang: Comparison of different aggregation methods (mean, slope and principal component) for phenotypic genetic linkage analysis of longitudinal hypertension. In: Genetic Workshop of International Society of Genetic Epidemiology13; 2002; Los Angeles, New Orleans, USA. 128- 132.
78.s Rao, G Shen, R Cannata, E Zirzow, RC Elston, X Li, L Li, EF Plow, Q Wang: Heredity and linkage analysis of early-onset coronary heart disease and its related traits based on 428 identified multiple families. Genetic epidemiology 2002, 23:30 1. (SCI)
77. Li Li, Li Xia, Wang, Study on the Validity of Two Filtering Feature Gene Selection Algorithms. Life Science Research, 2003, 7(4):369-373.
76. Li Chuanxing, Li Xia, Correlation Analysis of Gene Expression in Regulatory Pathways, Genetics, 2004.
75. Wang Haiyun, Li Xia, Zheng Guo, Zhang Ruijie, Comparative study of four pattern classification methods in gene expression profile analysis, Journal of Biomedical Engineering, 2004.
74. Gong Binsheng, Li Xia, Zheng Guo, Function and application of SAGE gene analysis system, China Journal of eugenics 2002-10/.
73. Xu Na, Li Xia, Du Lei, Li Li, similarity analysis of function-driven gene expression, Harbin Medical University, 2003,37 (6)183-186.
72. Zhang, Li Xia, Tu Kang,,,. Analysis of the relationship between gene function and expression by GeneHub software, journal of biomedical engineering, 2004. (accepted)
7 1. Hui Yu, Zheng Guo, Li Xia, Tu Kang. Cluster analysis method of gene functional modules related to experimental conditions. Journal of biophysics, 2004 (accepted)
70. Correlation analysis of corresponding gene expression in Wang Leyan, Zheng Guo, Li Xia, Tu Kang, Xu Jianzhen, Hui Yu, Gong Binsheng and protein, Journal of Harbin Medical University, 2003.
69. Zhu Jing, Zheng Guo, Li Xia, Gong Binsheng, Tu Kang, Hui Yu, Xu Jianzhen, Correlation analysis of gene expression encoding protein in the same signal transduction pathway, Journal of Harbin Medical University, 2003.
68. Liu Shuai, Zheng Guo and Li Xia. Cluster analysis of systematic variation of gene expression profile in cancer cell lines, CCML, 2004.
67. Hui Yu, Zheng Guo, Li Xia. Mining functional categories of characteristic genes based on GO and gene expression profile. Bioinformatics. 2003, 1 (1), 15- 19.
66. Xu Wang Qixia. Software IDEA and WebGEA for gene expression profile information analysis. Bioinformatics, 2003. 1( 1):33-36.
65. Tu Kang, Hui Yu, Zheng Guo, Li Xia. Algorithm for mining association rules between GO functional classes and gene differential expression. Advances in biochemistry and biophysics. (accepted)
Gao Guangxin, Li Xia, Zheng Guo. Statistical methods and procedures of genetic heterogeneity, China Health Statistics 200 1, 18 (3), 169.
Li, Functions and Menu Structure of Computer System for Population and Family Data Analysis of Human and Medical Genetics (2) China Journal of Eugenics and Genetics1997; 5( 1)
62. Li, Functions and Menu Structure of Computer System for Population and Family Data Analysis of Human and Medical Genetics (3) China Journal of Eugenics and Genetics1997; 5( 1)
6 1. Zheng Guo, He Ying, Li Xia, methods for estimating recurrence risk in genetic counseling; China Journal of Eugenics and Genetics1997; 5(2)
(page 92)
60. Zhang Ruijie, Zheng Guo, Li Xia, A nonparametric scoring algorithm based on gene expression profile analysis and its boundary determination method, 2002; Journal of Mathematical Medicine
59. Zheng Guo, Li Xia, Feasibility study on detecting gene mutation types by analog gene chip, 2002; Journal of Mathematical Medicine
58. Gong Binsheng, Li Xia and Zheng Guo. Introduction and Application of SAGE System, China Journal of Eugenics and Genetics, 2002.
57. Xu Jie, Zheng Guo and Li Xia. Simulation analysis of the feasibility of distinguishing gene mutation types by expression profile, Journal of Mathematical Medicine, 2002.
56. Xu Jie, Zheng Guo and Li Xia. Comparison of single hidden layer and double hidden layer neural networks in predicting the secondary structure of protein. Journal of Harbin Medical University, Volume 35, No.6, 200 1- 12.
55. Zhang Ruijie, Xu Jie, Zheng Guo and Li Xia. Nonparametric method for identifying differentially expressed genes in microarray, Journal of Mathematical Medicine, 2002,
54. Gene expression profile analysis of different types of glioma, such as Jiang, Pu, Xu Jie, Li Xia, etc., Journal of Oncology 2002- 10.
53. Xu Kang, Study on the classification method of gene expression profile in tissue samples, China Health Statistics 2002,
52. Wang Mujie, Zheng Guo, Li Xia Design Drug Administration Scheme Based on First-order Absorption (First-order Parallel) Michaelis Process: Extravascular Administration, Journal of Biostatistics, 2002.
5 1. Zhang Shiqian, Li Xia, Zheng Guo, Genetic linkage analysis and risk factors of cardiovascular diseases, Harbin Medical University, 2002.
50. (Li) (According to the pharmacokinetic design, according to the Michaelis process (first-order parallel), the dosage regimen was eliminated: intravenous injection, medical information processing and research1997; 5( 1)(P7)
49. (Zheng Guo, He Ying, Li Xia) Some statistical methods and their program applications in the study of genetic heterogeneity, Medical Research and Practice1996; 4(5)(P395)
48. Li) Population Pharmacokinetic Analysis System and Pharmacokinetic Simulation System, Medical Research and Practice1996; 4(5) (page 437)
47. (Zheng Guo, He Ying, Li Xia) Pharmacokinetic evaluation of Michaelis elimination drug administration scheme: intravenous drip, Acta Biomedical1996; 1 1(4)(p 13 1)
46. (Zheng Guo, Li Xia) Numerical solution of steady-state property analysis of drugs based on (first-order parallel) Michaelis process, Acta Biomedical1996; 1 1(4)(P2 10)
45. Calculation Method of Heritability Estimation (Li Ruijie), Disease Surveillance1996; 1 1(3-A)(P222)
44. (Li Zheng) Path analysis method and its program and its application in genetic research, chinese primary health care1996; 10( 1 1)(p 4 1)
43. (Zheng Guo, He Ying, Li Xia) Design and Evaluation of Praziquantel Administration Scheme for Cerebral Cysticercosis, china journal of modern medicine1996; 6(3)(P 1 1)
42. (Li Zheng, Wang Mujie) Pharmacokinetics was applied to evaluate the administration scheme of elimination drugs according to the Michaelis process: intravenous injection, Journal of Mathematical Medicine1996; 9(3)(P 198)
4 1. (He Xia) Analysis of the administration regimen of albendazole in the treatment of cerebral cysticercosis, Journal of Mathematical Medicine1996; 9(4)
(P343)
40. (Li Jing, Li Xia, Zheng Guo) Quantitative analysis of B-ultrasound images and its application in TCM syndrome differentiation of liver diseases, journal of traditional chinese medicine1996; 1
(page 56)
39. (Li Zheng) Using pharmacokinetics to design a drug administration scheme to eliminate drugs according to the first-order process: intravenous drip, Journal of Disability Medicine1996; 4(3)(P 1 18)
38. (Li) Haplotype Association and Linkage Analysis, Foreign Journal of Medical Genetics1996; 19(6)(P293)
37. (Zheng Guo, He Ying, Li Xia) Function and menu structure of computer system for population and family data analysis of human and medical genetics (Ⅰ), China Journal of Eugenics and Genetics1996; Page 4(6) (Page 7)
36. (Zheng Guo, Li Xia, Liu) Introduction of computer-aided diagnosis and inquiry system for malformation syndrome, China Journal of eugenics1995; Article 3, paragraph 5 (P2)
35. (Gao Guangxin, Li Xia, Zheng Guo) Procedure and application of disease heritability estimation, chinese primary health care; 200 1， 15(6)(P55)
34. (Zheng Guo, Li Xia, He Ying) Mixed analysis of serum uric acid concentration in China population, China Journal of Eugenics and Genetics1995; 3(6) (page 48)
33. (Zheng Guo, Li Xia, He Ying) Computer-based Drug Administration Scheme Evaluation System, Medicine and Computer1995; 3 (page 290)
32. (Li) General Pharmacokinetics Computer Analysis System, Medicine and Computer1995; 3 (page 288)
3 1. (Zheng Guo, Li Xia, He Ying) Pharmacokinetics was applied to design the administration scheme according to the first-order process: intravenous drip, drug, computer1995; 4 (page 286)
30. Age distribution and risk analysis of hereditary diseases in summer, Foreign Medical Genetics Volume1995; 18(2)(P98)
29. Mixed analysis method for the detection of main effect factors of quantitative traits in summer, Volume of Foreign Medical Genetics1995; 18(3)(P 128)
28. (Zheng Guo, Wang Mujie, Li Xia) Scheme design of eliminating extravascular administration and intravenous administration according to the first-level process, medical information processing and research1995; 3(2)(P 13)
27. (Zheng Guo, He Ying, Li Xia) Mixed analysis of blood sugar concentration distribution in northern China, China Health Statistics1995; The second volume on page 49
26. (Li Mujie) AGFAP method for genetic pattern analysis and its program application, Journal of Mathematical Medicine1995; 8(2)(P 145)
25. (He Yingxia) Estimation of polymorphic haplotype frequency and linkage disequilibrium parameters: procedures and applications, Journal of Mathematical Medicine1995; Article 8, paragraph 3 (page 269)
24. (Zheng Guo, Li Xia, Wang Mujie) Mixed analysis of serum triglyceride concentration distribution in China population, Journal of Harbin Medical University1995; 29( 1)(P9)
23. (Zheng Guo, Li Xia, He Ying) Method and procedure of nonlinear mixed effect model of population pharmacokinetics, Journal of Clinical Medical Engineering1994; 2( 1)(P24)
22. MASC method for genetic pattern analysis and its computer program, Journal of Clinical Medical Engineering1994; 2( 1)
Fourth, the main works:
1. Data analysis of drugs, receptors, enzymes and immune reaction kinetics, Heilongjiang Science and Technology Press, first author,1996;
2. Computational Molecular Biology and Genome Informatics, second author, Heilongjiang Science and Technology Press,1998;
3. Data Analysis of Medical Genetics and Genetic Epidemiology, second author, Heilongjiang Science and Technology Press,1996;
4. Medical Fuzzy Mathematics, Harbin Institute of Technology Press, second author,1993;
5. Advanced Mathematics in Medicine, hosted by Heilongjiang Science and Technology Press, 2000;
6. Medical Statistics Problem Set, Heilongjiang Science and Technology Press, presided over, 2000;
7. Medical information analysis method, Harbin Publishing House, second author, 2001;
8. Advanced Mathematics in Medicine, Harbin Publishing House (200 1 editor);
9. Fundamentals of Probability Theory and Information Theory, Harbin Publishing House (hosted in 2003);
10. Theory and Practice of Modern Bioinformatics, edited by Science Press, published in June 2005.