First of all, there is a family genetic history (strong evidence)

Familial amyotrophic lateral sclerosis (FALS) accounts for 5-7% of all ALS; The remaining cases are sporadic cases.

2. Age > 40 years old (strong evidence)

Worms PM, a French epidemiologist, believes that the prevalence rate of ALS increases after 40 years old, with the highest prevalence rate at 57 years old, and then the prevalence rate will gradually decrease.

The age of onset is related to the speed of disease progression. Patients with younger onset age progress slightly slower than older patients.

Third, the history of military service (insufficient evidence)

Fourthly, the history of professional sports (weak evidence)

Verb (abbreviation for verb) smoking history (insufficient evidence)

The risk of ALS increases with exposure to tobacco, which is positively correlated with the number of smoking packages per year, smoking history and (possibly) gender (female smokers are more dangerous than men).

Six, agricultural chemicals exposure history (weak evidence)

Studies have shown that occupational exposure to pesticides, herbicides, insecticides, fungicides and fertilizers is positively related to the prevalence of amyotrophic lateral sclerosis.

Seven, lead exposure history (weak evidence)

Studies have found that people with a history of occupational exposure to lead (more than 200 hours in their lifetime) have an increased risk of amyotrophic lateral sclerosis.

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