Glutathione reductase is the substance that keeps glutathione in a reduced state;

Glutathione, as an important substance regulating metabolism in cells, is not only the auxiliary group of glyceraldehyde phosphate dehydrogenase, but also the coenzyme of glyoxalase and triose dehydrogenase. Glutathione participates in the tricarboxylic acid cycle and sugar metabolism in vivo, and can activate many enzymes, such as sulfhydryl (SH) enzyme-coenzyme, so as to promote the metabolism of sugar, fat and protein.

glutathione molecule is characterized by its active sulfhydryl group (-SH), which is the most important functional group. It can participate in many important biochemical reactions in the body, protect sulfhydryl groups, an important enzyme protein in the body, from oxidation and inactivation, and ensure energy metabolism and cell utilization.

At the same time, it can directly reduce free radicals into acidic substances through the combination of sulfhydryl groups with free radicals in the body, thus accelerating the excretion of free radicals and resisting the damage of free radicals to important organs. Haddad and other studies have found that GSH is involved in the regulation of cytokine transcription induced by lipopolysaccharide and the regulation of I-KB/NF-KB signaling pathway.

Armstrong et al. found that the decrease of GSH content is a potential early activation signal of apoptosis, and the oxygen free radicals produced subsequently promote cell apoptosis

Extended data:

Glutathione, as an important antioxidant in the body, can scavenge free radicals in the human body; Because GSH itself is easily oxidized by some substances, it can protect sulfhydryl groups in many molecules such as protein and enzymes from being oxidized by harmful substances in vivo, thus ensuring the normal physiological functions of molecules such as protein and enzymes;

There are a lot of glutathione in human red blood cells, which is of great significance to protect the sulfhydryl group of protein on the red blood cell membrane from hemolysis.

Glutathione drugs are widely used in clinic. Besides using its sulfhydryl group to chelate toxic substances such as heavy metals, fluoride and mustard gas, they are also used in hepatitis, hemolytic diseases, keratitis, cataract and retinal diseases, etc., as drugs for treatment or adjuvant treatment. In recent years, western scientists, especially Japanese scholars, have found that glutathione has the function of inhibiting HIV.

The latest research also shows that GSH can correct the imbalance of acetylcholine and cholinesterase, play an antiallergic role, prevent skin aging and pigmentation, reduce the formation of melanin, improve skin antioxidant capacity and make skin shiny. In addition, GSH also has a good effect in treating corneal diseases and improving sexual function.

Glutathione.