Shan Ge, a professor and doctoral supervisor at the School of Life Sciences, University of Science and Technology of China, is a candidate for the Hundred Talents Program of Chinese Academy of Sciences (21). Chinese name: Shan Ge Nationality: China Occupation: Professor, School of Life Sciences, University of Science and Technology of China Graduate School: Profile of Lanzhou University, research direction, main contributions, main research, representative papers, profile of people: Bachelor of Cell Biology, Lanzhou University, 1995; Master of Shanghai Institute of Cell Science, Chinese Academy of Sciences, 1998; Ph.D., Georgia State University, 24. He has successively conducted postdoctoral research in Emory University and Yale University (tutor Sidney Altman, one of the discoverers of RNase, and the 1989 Nobel Prize in Chemistry). In 21, he joined China University of Science and Technology. He has been engaged in the research on gene expression regulation and the function and functional mechanism of non-coding RNA for a long time. We discovered new types of non-coding RNA, studied new functions of non-coding RNA, revealed new mechanism of non-coding RNA, and explored new research methods of non-coding RNA. Since the establishment of the laboratory, it has been in Natural Structural &; MolecularBiology, NatureCommunications and P.N.A.S have published many research papers in the field of non-coding RNA. At present, he undertakes the projects of the National Natural Science Foundation of China and the National Major Scientific Research Program 973. The research direction mainly includes gene expression regulation, the function and mechanism of non-coding RNA, and the development and differentiation of central nervous system in model animal. The main contributions are as follows: 1) The regulation of animal gene expression by environment (through non-coding RNA) 2) The regulation and function of non-coding RNA (such as naturally occurring antisense RNA in animal cells) 3) The function of transcription and post-transcription regulation in model animal (nematodes and mice) The representative paper Limindai Chuang Liang Chen Geshan Z. haoyongLi.AlteredexpressionofmicroRNAsintheresponsetoERstress Science Bulletin 1 January 215 Shan G . RNA interference as gene knockdown technique . The International Journal of Biochemistry & Cell Biology . 21. 42(8):1243-51. (Invited Review) Luo Y*, Shan G *, Guo W*, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X.*Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult NeuralStem/ ProgenitorCells. PLOS Geics 21. 6(4):e1898. (*Co-first authors). 3.Shen N, Ko J, Xiao G, Wesolowski D, Shan G , Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by the EGS technology. P.N.A.S .， 29. 16(2): 8163-8. 4. Shan G , Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, Jin P. A *** all molecule enhances RNA interference and promotes the biogenesis of microRNAs. Nature Biotechnology . 28. 26(8) :933-4. 5. Shan G , Walthall WW. Copulation in Caenorhabditis elegans requires a Nuclear Hormone Receptor. Developmental Biology . 28. 322(1):11-2. 6. Shan G , Kim K, Li C, Walthall WW. Convergent geic programs regulate similarities and differences beeen related motor neuron classes in Caenorhabditis elegans. Developmental Biology . 25. 28(2):494-53.