If this situation is caused by congenital metabolic disorder of folic acid, it is generally caused by genetic factors. It is necessary to take folic acid tablets properly and eat leafy vegetables for treatment.

Clinical significance of gene detection of folate metabolism ability;

1. Predict the risk of neonatal birth defects and cardiovascular and cerebrovascular diseases;

2. Provide guidance for pregnant women with MTHFRC677T gene mutation, and increase folic acid intake at different times during pregnancy;

3. Detection of MTHFRC677T gene can provide diagnostic basis and medication guidance for patients with high HCY level or abnormal folic acid metabolism.

Detection of MTHFR genotype in the following population:

1, patients with essential hypertension (predicting the risk of stroke and coronary heart disease);

2. Hypertensive patients with elevated homocysteine (Hcy);

3. Hypertensive patients with risk factors such as hyperlipidemia and hyperglycemia;

4. Stroke patients (targeted treatment to reduce the recurrence rate of cardiovascular and cerebrovascular diseases);

5. People with a family history of stroke;

6, prenatal and postnatal care for pregnant women, guide folic acid intake, prevent fetal birth defects.