Male, professor, doctoral supervisor. Doctoral supervisor of biomedical engineering. 20 1 1 was selected as "outstanding talents in the new century" by the Ministry of Education. On April 20 16, he was elected as a young scholar of "Changjiang Scholar Award Scheme". Professor of Harbin Institute of Technology.
20 18, 1 1, won Tan Life Science Innovation Award.
Chinese name: Huang Zhiwei.
Nationality: China.
Occupation: teacher
Graduate school: Lanzhou University of Technology
Main achievements: "Outstanding talents in the new century"
Representative works: NatureCellBiology；; Microbial pathogenicity
Title: Professor
Character experience
Doctoral supervisor of biomedical engineering. Bachelor of Chemical Engineering and Technology in Lanzhou University of Technology in 2003; In 2008, Beijing Institute of Life Sciences (NIBS) and China Agricultural University jointly trained doctors; From 2009 to 20 12, I worked as a postdoctoral fellow in LaurieH Laboratory. Department of immunology and infectious diseases, Harvard University. 20 1 1 was selected as "outstanding talents in the new century" by the Ministry of Education.
Character honor
On August 3, 20 18, according to the relevant provisions of the Measures for the Administration of National Science Fund for Distinguished Young Scholars, the National Natural Science Foundation of China published the list of applicants for the recommended projects of National Science Fund for Distinguished Young Scholars in 20 18, and Huang Zhiwei was on the list.
20 18, 1 1, won Tan Life Science Innovation Award.
research direction
The research in our laboratory is divided into two parts:
1. Relationship between structure and function of important biological macromolecules (soluble/membrane proteins and nucleic acids) in immunology and neurobiology. Cell surface receptors sense and respond to extracellular signals like antennas. We studied the relationship between the structure and function of receptor/ligand complex on membrane, which is involved in important cell signal transduction. Our research will be used to answer the following questions: How are ligands recognized by corresponding receptors (such as GPCRs) on the cell surface? How are their mutual recognition specificity/selectivity achieved? What changes have taken place in the conformation of the receptor after binding the ligand? How does the change of receptor conformation activate or inhibit intracellular signaling pathways? How do regulatory proteins regulate the function of receptors? In addition, we also studied the relationship between the structure and function of protein (complex) in important cells involved in immunity and nerve signal transduction.
2. Study on new genes activated by natural immune system and their signal pathways: signal molecules regulating the differentiation and activity of immune cells (such as macrophages) and their signal transduction mechanisms, and inflammatory body activation.
In addition to the basic research of structural biology and signal pathway, we also analyzed the structure of soluble/membrane protein (complex) which plays a key role in immune and neurodegenerative diseases, and used these structural information to reasonably design small molecular drugs to treat the above diseases. The research results were published in Cell Host &; Microorganism (IF= 13.728), natural structure and biochemistry; Molecular biology (if = 13.685) and other journals.
Molecular mechanism of interaction between virus and host immune system.
Main contribution
1. Wei Guozu, Chen Xi, JaeShim, Huang Zhiwei, NicholasBrady, DorothyHu, RebeccaDrapp, KirstenSigrist, LaurieH. Glimcher，Dallas Jones(20 1 1). 3 ubiquitinligasewwp 2 regulated scraniofacialdevelopment throughmonouptinationofgoosecoid . nature cell biology . 13，59-65。
2. Chen De, Rey, Flores, Huang Zhiwei, Uzi, Chai Ji, Zhong. (20 10). Automatic treatment and self-activation of infected cells. Pathogenic mechanism of microorganisms. 1( 10)， 1- 10。
3. Zhi Wei Huang and Ji Jie Chai (20 10).
4. Huang Zhiwei *, Salahi. Sutton *, Adamje. Robert Wallenfang. Orchard, xiaojingwu 1, rich in talents, assembly site ChaiandNealM. Alto(2009). Molecular biology. 16(8)，853-860。 (* Co-first author, this publication was selected as "key research" by NatureChina)
5. Huang Zhiwei, Ying Cai Feng, Chen Ding, Xiao Jingwu, Wang Xiaojun, Xing Guoxiao, Li Wenhui, Niuhuang, Li Chuangu, Guangming Zhong and Ji Jie Chai (2008). Microorganisms. 4(6)，529-542。 (thipublicationwasselectedasaresearch“highlight”by nature China)
6. McBride, Olson, Huang Zhiwei, Neil. Alto, Jack. Dixon, Ji Jie Chai and Sam Ellie. Miller (2008). The structure and function of salmonellasifaindicathatits introduce internal sound adjustment into the interaction with SKIP, SseJ and hofamilygtpases. Cellhost & microorganism. 4(5)，434-446。