1. It is easy to form insoluble complexes with antacids such as sodium bicarbonate and divalent or trivalent metal ions such as calcium, magnesium, aluminum, etc., reducing drug absorption.

Therefore, when the above drugs need to be used together, they should be administered 2 to 3 hours before and after taking the product.

2. Long-term combined use of phenobarbital, phenytoin or carbamazepine can shorten the half-life period of this product by inducing the action of liver enzymes.

CNS depression may occur during concomitant use with phenobarbital.

3. When combined with oral anticoagulants, this product can inhibit the synthesis of vitamin K by intestinal bacteria and strengthen the anticoagulant effect, which may cause bleeding.