The research team consists of researchers from University College London, Bristol University and Sanger Institute of Wellcome Trust. After analyzing the genome sequence data of 4000 healthy Britons, they found that a gene mutation named APOC3 was closely related to the level of triglycerides in blood. The blood triglyceride level of people with this gene mutation is significantly lower than that of people without this gene mutation, and their risk of cardiovascular disease is far lower than that of ordinary people.

This genetic variation is very rare. According to the researchers, only about 0.2% people will carry this variant gene.

Researchers believe that the discovery of this mutant gene has important clinical significance. Once the protective mechanism of this mutant gene is clarified, scientists can develop new therapies to help those at high risk of cardiovascular disease.