Three research clusters:
State key laboratory of molecular biology
State key laboratory of cell biology
Shanghai National protein Scientific Research Center (to be established)
Five frontier areas:
Gene regulation
ribonucleic acid
experimental embryology
Protein science
Cell signal transduction
Cell and stem cell biology
Mechanism of canc and other major diseases
Public * * * technical support platform:
Cell analysis technology platform
Animal experimental technology platform
Molecular biology technology platform
Chemical biotechnology platform
Stem cell technology platform
Zebrafish technology platform
Drosophila resources and technology platform
During the Twelfth Five-Year Plan and Innovation 2020, the Institute will strive to make breakthroughs in three scientific issues: chromatin structure and function regulation, cell lineage establishment and transformation regulation, and cell signal transduction regulation on inflammation/tumor. In 2009-20 1 1 year, the Institute added 44 competitive scientific research projects (projects) 184 from the Ministry of Science and Technology, the National Natural Science Foundation of China, the China Academy of Sciences and the Shanghai Science and Technology Commission, and obtained 373 million yuan in competitive funds.
Major scientific research projects (2009-20 1 1 year)
A major scientific research project initiated by Shanghai Institute of Biochemistry and Cytology in history.
Pilot scientific and technological project of stem cell strategy
The strategic pilot science and technology project "Stem Cell and Regenerative Medicine Research" is the only biological project among the first batch of strategic pilot science and technology projects initiated by China Academy of Sciences, and it is an important part of the implementation plan of "Innovation 2020". The first phase was implemented for five years (20 1 1-20 15), with a total investment of 920 million yuan.
The Institute of Biochemistry and Cytology actively undertakes special scientific research tasks, with Jingnaihe Institute as the special director of "Establishment of Cell Pedigree Based on Developmental Regulation", 13 researchers as the academic backbone of the first, second and fourth special projects, and the sub-project contract fund is1070,000 yuan. The special project started at the beginning of 20 1 1 and made significant progress on 20 12. As of July 20 12, 1 Cell, 2 Nature, 1 Science and 1 Cell Stem Cells have been published. Natural Cell Biology 1 article, Developmental Cell 1 article, Molecular Cell 1 article. Published SCI papers (as of 20 15.05438+0.3 1)
Articles published in Biochemistry and Cell must be important scientific research progress, both in English. Basic research articles are different from social science and other liberal arts papers, and there is no plagiarism. Please respect those scientists who work hard. )
20 15, 8 articles, natural 1.
There are 64 articles in 20 14, including CNS (three top journals of life Sciences such CNS(Cell, Nature and science) and 6 sub-journals.
There are 66 articles in 20 13, including 5 CNS articles.
On July 20th, 200912, the Institute published 388 SCI papers, including:
* Published 6 papers in top international journals, including 2 in Cell, 2 in Nature, and 1 in Science/kloc-0.
* Published 59 papers in world-class journals, including 2 in Cell Stem Cells, 3 in Developing Cells, 0 in Molecular Cells/KLOC-0 and 2 in Blood. ...
Influencing factors of SCI papers published by biochemical cells in 200 1-20 1 1 year.
Note: Impact factor is an indicator of the importance (quality) of an article, and its correctness is controversial. However, it should be noted that in China, articles with an impact factor greater than 5 are considered as extremely high-level work results, while most published SCI articles (including some domestic magazines) often have zero or no impact factors.
2001-201/impact factors published by the institute >: JBC(2004, impact factor 2065438+4.60) accounted for all SCI papers, and Shanghai Institute of Biochemistry and Cell obtained 2001-201.
Award-winning achievement (200 1-20 13) Name of achievement Award-winning time Award-winning name Award-winning unit/grade unit/Ordering research on DC cell activation regulation and Th cell differentiation mechanism in immune-related diseases 20 13 Second Prize of National Natural Science Award 1 New tumor-targeted gene-virus therapy (CTGVT) 20 3 Second Prize of Shanghai Natural Science Award 1 Nudel Protein in Cell Division, Function and Mechanism of Action in Migration and Intracellular Transport 20 12 First Prize of Shanghai Natural Science Award 1 Outstanding Contribution Award of Shanghai Youth Science and Technology (Li Jinsong) 20 12 RNA Structure of Pathogenesis, Diagnosis and treatment of Alzheimer's disease and related cognitive impairment 20 1 kloc-0/Shanghai Shanghai Science and Technology Progress Award Function 2009 Shanghai Natural Science Award Second Prize1 The new mechanism of opioid signal transduction and its role in addiction won the first prize of Shanghai Natural Science Award in 2009.2 Recognition of substrate by leucyl -tRNA synthase won the second prize of Shanghai Natural Science Award in 2008 1 Molecular basic research on epididymal sperm maturation/Dialogue mechanism between 654 won the second prize of National Natural Science Award in 2008 and other cell signal pathways 1, Second prize of National Natural Science Award in 2007, molecular basic research on epididymal sperm maturation in 2007, first prize of Shanghai Natural Science Award 1G, dialogue mechanism between protein-coupled receptor signal and other cellular signal pathways in 2006, first prize of Shanghai Natural Science Award 1, molecular mechanism of cytokine neuromodulation in 2006, and third prize of Shanghai Natural Science Award 2 ribosome inactivating protein. Study on the Structure and Function of Ribosomal RNA 2005 Second Prize of National Natural Science Award 1 Study on the Structure and Function of Active Polypeptide Toxin 2005 First Prize of Shanghai Natural Science Award 1 Method of Producing Biological Products by Bombyx mori Bioreactor 2004 Second Prize of National Technological Invention Award 2 Shanghai Science and Technology Hero (Zhang) Study on the Structure and Function of Ribosome Inactivating Protein and Ribosome RNA Shanghai Science Award 2003 Second Prize of Shanghai Natural Science Award 1 Research System and Development of Recombinant Genetic Engineering Drug Coagulation Factor FVIII 2003 Third Prize of Shanghai Natural Science Award 1 Space Cell Electrofusion 2003 Third Prize of Shanghai Science and Technology Progress Award 3 Second Prize of Recombinant Human Epidermal Growth Factor 2002 National Science and Technology Progress Award. Award 1 Role of Protein Kinase in Opioid-mediated Signal Transduction and Tolerance Dependence 2002 National Natural Science Award 2 Recombinant Human Epidermal Growth Factor 200 1 Science and Technology Progress Award of China Academy of Sciences 1 Role of Protein Kinase in Opioid-mediated Signal Transduction and Tolerance Addiction 200 1 Shanghai Natural Science Award 2 Cloning and Expression of Antigen Gene of Schistosoma japonicum Chinese mainland Strain and Evaluation of Animal Protection Effect 200 1 Shanghai Science and Technology Progress Award 2 Experimental Research on Neurofunctional Imaging and Gene Therapy in the Pathogenesis of Parkinson's Disease 200 1 Shanghai Science and Technology Progress Award 2 aminoacyl -trna Synthase and Its Related Interaction -tRNA 200 1 National Science Award 2/KL.
Authorized PatentNo. Patent Name Authorized Inventor Patent Type 2007 10040600.0 Regulator of Interaction between Fluffy Protein and β -catenin 20 12- 19 Li Jiyong Wei Invention Patent 2007 10044543.3 Cholesterol Metabolism Regulatory Protein and Its Use 20076543+02. Kloc-0/-07 Invention Patent Xie Regulatory Drug Screening System and Method 20 12-09- 12 Song Baoliang Tang Jingjie Invention Patent 2009 10055694.8 Method and Reagent 2012-09-/Kloc-. 2 Jin Shiyizhao's invention patent 200965438+ 9 monoclonal antibody and its preparation method and use 20120965438++02-09-12 Li Liu Xiaojiang Haiyang's invention patent 2008 10042946.9 Stable expression of cell cycle factor FoxM 1. Methods 20 12-08- 15 Wang Xin Ding Xiaoyan Li Fuming's invention patent 200710038085.2 Application of α -synuclein drug screening for Parkinson's disease 20 12-08- 15 Hu Hongyu's invention patent in Xie Yuanyuan Lin Donghai. Screening of Heterogeneous Ribonucleoprotein K and Its Application 20 12-07-25 Zeng Hongyang, Xia Qichang and Li Yexiong Invention Patent 2008 10207233.3 Interference Molecules Inhibiting the Expression of TM4SF4 and Its Application 20 12-07-25 Zhao et al. Invention Patent 2006125 Synthesis method of adenosylmethionine 20 12-07- 18 Zhao Fukun, Luo Yunxing and Yuan Invented Patent 200910051004.1Solid-phase sumo system and solid-phase sumo removal system 20/kloc-0. 3005.9 A Method of Recombinant Expression of Soluble Transcription Mediator Complex Med23 Subunit 20 12-07-04 Invention Patent by Huang Xiaoyang 2004 10025465.9 Screening and Application of Hepatocellular Carcinoma Related Protein Molecular Marker Carcinoprotein 18 2012-07-07. Chen Xiong's invention patent US8 193 162B2 liver regeneration 20 12-06-05 Zhao, Liu Zhangwu, Qin Jia and Li Liping's invention patent 2008 10200207.8 transgenic construct and its application in preparing spatiotemporal adjustable liver injury model 20/kloc. 5438+00033254.8 Mouse allergic asthma model induced by trichosanthin 20 12-05-02 Mao Invention Patent 2008 10033086.2 Xenopus laevis XPAPC gene promoter and its tissue-specific enhancer 2012-0/-60. Lou Xin invention patent 2008 10037362.2 monoclonal antibody against H5N 1 derived hemagglutinin protein and its application 20 12-0 1-04 Sun Bingzhuang Xiao Xiao Ji Yongyong invention patent 20081004/kloc-0. -0 1-04 Chen invention patent 2005 10029 160. X. Application of Hexose (Phosphate) Kinase 20 12-0 1-04 Zeng Rong Yuan Xinyu Li Chen Zhou Xiao Invention Patent 200565438. Application No.2012-01-04 Zeng Rong Yuan Xinyu Li Chen Zhou Xiao Invention Patent 200510029155.9cd59 Application No.2012-01-04 Zeng Lirong Zhou Chen.
Main International Patents Obtained by Shanghai Institute of Biochemistry and Cell I. Training Objectives
1. Have firm socialist beliefs, love the motherland and abide by the law; Establish patriotism; Have the spirit of unity, peace-loving, diligence, courage and self-improvement; Have a rigorous scientific attitude and excellent style of study, have a strong sense of professionalism, and actively serve the country's modernization.
2. Master the solid and extensive basic theory and systematic and in-depth professional knowledge of this discipline, have the ability to engage in scientific research independently, have good scientific research ethics and scientific dedication, and make creative achievements in science or professional technology. 3. Physical and mental health.
Second, the training period
The academic system of master-doctoral students is five years, and the longest study period shall not exceed six and a half years. Graduate students should complete their study tasks within the specified time.
Third, the discipline and research direction
The first-level discipline for training graduate students is biology, which includes biochemistry and molecular biology, cell biology and developmental biology. The research direction has formed the fields of biochemistry and molecular biology with gene expression regulation as the main core and protein science and epigenetic regulation as the main line; And the field of cell biology, which takes the signal network of cell activities such as proliferation, differentiation, apoptosis and migration as the core, and the determination of cell behavior and fate, the development of stem cells and individuals as the main line.
Fourth, training methods.
1. After the postgraduate entrance examination, after 2-3 laboratory rotation studies, the tutor and students are selected in two directions to determine the tutor. Implement the tutor responsibility system in the process of postgraduate training. 2. After the graduate students enter the laboratory, under the guidance of the tutor, they determine the direction of scientific research, choose research topics, and the research institute will organize the opening report in a unified way. Graduate students enter the thesis work according to the comments of the opening report. 3. Master-doctoral students are trained as master students when they enter school, and they are assessed in the second semester of the second academic year after entering school, that is, doctoral qualification assessment. When a graduate student changes to a doctoral student, he must apply and get the recommendation of his tutor. The tutor group guides the graduate students' project work before the assessment, and the research institute organizes the assessment group to audit according to the graduate students' academic performance and the content of the research project. Those who pass the exam can study for a doctorate; Those who fail can have a second assessment opportunity after half a year. Those who fail eventually change to master's training or drop out of school. 4. At the beginning of the second year of Ph.D., the research institute will organize an evaluation team to evaluate and guide the progress of the project after the master-doctoral students switch to Ph.D., that is, the relative standard evaluation. Those who fail the examination can have a second examination after half a year, and those who still fail are advised to graduate with a master's degree. 5. In the third year of Ph.D., graduate students complete their professional summary according to the requirements of the Academy of Biological Sciences, and strengthen their in-depth understanding of their research fields. At the same time, the institute organized a work progress evaluation. If graduate students have reached the requirements of publishing papers for postgraduate defense before the assessment, they can not participate in the assessment of work progress, and then they need to apply and submit the published papers. Students who fail the exam are advised to graduate with a master's degree or drop out of school. 6. In order to broaden students' knowledge, graduate students should attend all kinds of academic reports at least six times each semester, and submit the title, time, speaker and 100 word summary or experience of each report at the end of each semester. China Academy of Sciences, Shanghai Institute of Life Sciences, postgraduate scholarship level, master's degree, master's degree, master's degree, doctor's degree, master's degree, master's degree, master's degree, master's degree, master's degree, master's degree, master's degree.
All students studying in graduate department charge tuition.
Since the second half of 20 14, scholarships have been slightly improved.
The scholarship is shared by the National Science and Technology University and the laboratory. Take 2,500 yuan (20 15) in the second year as an example, the National Science and Technology University of 500 yuan, and the rest will be awarded by the laboratory.
In addition to basic scholarships, Chinese Academy of Sciences graduate students also have many competitive scholarships and various benefits.