2. Key projects of National Natural Science Foundation: Exploratory study of fluorescent imaging probes for tracing molecular events in living cells No.2 1035003, 201-2014.
3. The basic research project of scientific instruments of National Natural Science Foundation: fluorescence analyzer No.2 1035003, 20 13-20 16, which is suitable for detecting small molecular species in single cells. Professor Tang Bo has published more than 240 SCI papers in j.am.chem.soc., angew.chem.int.ed., adv.funct.mater., anal.chem., biomaterials, labchip, chem.com.mun, Chem. EUR. J. , and the impact factor is greater than 5.0. Representative papers are:
1., Liu Wei, Ping Li *, Xiao Haibin, and Tang Bo *. A fluorescent nanosensor for glycoprotein, whose activity is based on the target molecularly imprinted spatial structure and borate affinity. A new one. Chemistry. Edited by …, 2014,53,12489-12493.
2. Ping Li, Hu Xiufen, Sun Chuanzhi, Chen Dezhan and Tang Bo *. Dynamic reversible fluorescence imaging of superoxide anion fluctuation in living cells and in vivo. J. Am。 Chemistry. Socialists, 2013,135,14956-14959.
3. Li Na, Zhang Chenyang, Pan Wei, Tang Bo. Multicolor nanoprobes for detection and imaging of tumor-associated mRNAs in living cells. Angie. Chemistry. Edited by …, 2012,51,7426-7430.
4. Yu Fa Biao,,, Xia Duan, and, a near-infrared neutral pH fluorescent probe for monitoring tiny pH changes: imaging of living HepG2 and HL-7702 cells. J. Am。 Chemistry. Socialists, 2009,131,3016-3023.
5. Bo. Tang *, Xing Yanlong, Yu Fabiao, Yang Guiwen, a rhodamine fluorescent probe with N bond and its application in living cells. J. Am。 Chemistry. Socialists, 2007,129,1666-11667.
6. Dong Yubin, * Wang Peng, Xia, Tang Bo * and Ru, the nano lanthanide molecular lamp driven by coordination has adjustable luminous performance. J. Am。 Chemistry. Socialists, 2007, 129, 4872-4873.
7. Dong Yubin, * You-,* Tang Bo, * Ru-Qi Huang, and Stuart R. Batten, Temperature-controlled Synthesis Based on Metal-organic Frameworks with Acyclic Crown Ether Bridged Tetradentate Ligands with Bidirectional Coordination Donors. J. Am。 Chemistry. Socialists, 2007,129, 4520-4521.
8. Dong Yubin, * Zhang Qiang, Li, * Tang Bo and Ru, Cu (C2H4 22n4o3) CH2Cl2: a breathing discrete metal macrocycle, showing selective reversible object adsorption and maintaining monocrystal. J. Am。 Chemistry. Socialists, 2007,129,1514-15.
9. Yu Zhengze,,, Korea, and *. A near-infrared light triggered nanocarrier with reversible DNA valve for controlled release in cells. Advanced features. Mater , 20 13, 23, 2255-2262.
10.,,, Ma, Lu, etc. A near infrared ratio fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells. Chemistry. Sci。 , 20 13, 4, 255 1-2556.
1 1., Xu, Qiang Mingming,, Su Ruixian,,, Xie,, Kong,. A near infrared reversible fluorescent probe for real-time imaging of redox state changes in vivo. Chemistry. Sci。 , 20 13, 4, 1079- 1086.
12., Li Xi,, Yao He,, and Fan Chunhai. Nano-optical probe for cell imaging. Chemical Social Review, 20 14, 43, 2650-266 1.
13., Ji,,, Cui, Xu,,. Dual-functional combination Au-Fe2O3 nanoparticles for inducing specific apoptosis of cancer cells and real-time imaging. Biomaterials, 2012,33,3710-3718.
14. Ma Yu, Su Hao, Kuang Xuan, Li Xiangyuan, Zhang Tingting and Tang Bo *. Heterogeneous nano-metal-organic framework fluorescent probes are used to detect hydrogen sulfide in living cells with high selectivity and sensitivity. Anal. Chemistry. , 20 14, 86, 1 1459- 1 1463
15., Lu Li, Wang Qian, Duan Lili and Tang Bo *. Synergistic amplification based on graphene fluorescent switch: a sensitive and accurate method for detecting MicroRNA. Anal. Chemistry. , 20 14, 86, 5487-5493.
16. Lu Li, Wang Qian, Xiefeng, Lili Tong and Tang Bo *. Highly sensitive homogeneous detection of single living cell membrane protein based on microfluidic droplet aptamer and nicking enzyme-assisted signal amplification technology. Anal. Chemistry. , 20 14, 86, 5 10 1-5 107.
17., Li Yanhua, Korea,, and Tang Bo. A highly selective instantaneous nano probe for detecting and imaging ascorbic acid in living cells and in vivo. Anal. Chemistry. , 20 14, 86, 3924-3930.
18., Zhang Wen, Li Kexiang, Xiao Liu, Xiao Haibin, Andy and Tang Bo. Two-photon fluorescence probe based on mitochondrial targeting reaction for superoxide anion imaging in living cells and in vivo. Anal. Chemistry. , 20 13, 85, 9877-988 1.
19.,, Ye Jian,, Li Qingling,, Ji,, Zhang He * FRET-based bio-friendly Apo-GOx modified gold nanoprobes for specific and sensitive glucose sensing and cell imaging. Anal. Chemistry. , 20 13, 85, 972 1-9727.
20. Lu Li, Duan Lili,,, Xie,, Wang Qian and. High specificity and ultra-sensitive isothermal detection of MicroRNA by exponential rolling circle amplification based on padlock probe. Anal. Chemistry. , 20 13, 85, 794 1-7947.
2 1. Pan Wei, Yang Huijun, Zhang Tingting, Li Yanhua, Li Na * and Tang Bo *. Dual-targeted nanocarriers based on cell surface receptors and intracellular mRNA: an effective strategy for tumor cell imaging and treatment. Anal. Chemistry. , 20 13, 85, 6930-6935.
22. Kuang Xuan, Ma Yu, Su Hao, Zhang Jine, Dong Yubin and Tang Bo *. Enantioseparation of racemic drugs by high performance liquid chromatography based on pure chiral organometallic skeleton. Anal. Chemistry. , 20 14, 86, 1277- 128 1.
23. Li Qingling,,,,,, Xie,, and Tang Bo. Simultaneous determination of reactive oxygen species and nitrogen in mitochondria of apoptotic HepG2 cells and PC 12 cells based on microchip electrophoresis and laser-induced fluorescence. Anal. Chemistry. , 20 12, 84, 4687-4694.
24. Zhang Shan, Fan Nannan, Xiao Haibin,,, and Tang Bo. Quantitative fluorescence ratio imaging of chloride ions in lysosomes with single excitation and double maximum emission. Chemistry. Euro. j .，20 14，20， 1 1760- 1 1767。
25. Lu,,,, Yao,,,,,,, Ruan and Tang Bo. Screening and study of cyanine fluorescent probes for simultaneous detection of glutathione and cysteine under single excitation. Chemistry. Commun。 , 20 14, 50, 15439- 15422.
26. Ye Sujuan, Wu,, and *. A sensitive SERS analysis using triple helix molecular switch for cascade signal amplification to detect protein and nucleic acid. Chemistry. Commun。 , 20 14, 50, 9409-94 12.
27.,,,,, Xu, etc. Multifunctional gold-zinc oxide hybrid nanoparticles targeted lysosomal membrane permeability induction and imaging cancer cell apoptosis. Chemistry. Com door. , 20 14, 50, 8 1 17-8 120.
28. Li Na, Yang Huijun, Pan Wei, Wei Diao and Tang Bo. Nanocarriers triggered by tumor mRNA for multimodal cancer cell imaging and treatment. Chemistry. Commun。 , 20 14, 50, 7473-7476.
29. Xiao Haibin, Cheng Yinfang,,,, Hui Wang and Tang Bo *. A Near Infrared Fluorescence Probe for Monitoring Mitochondrial pH and Chemistry. Commun。 , 20 14, 50, 7 184-7 187.
30. Wang Yanhong, Li Qingling, Zhang Fumiao and Tang Bo *. Size-up immunomagnetic beads strategy for rapid detection of circulating tumor cells. Chemistry. Commun。 , 20 14, 50, 7024-7027.
3 1. Zhao Yingqiang,, Guan,,, Feng, Xin,. A new strategy to realize efficient space charge separation of carbonaceous photocatalyst. Carbon, 20 14, 73, 333-337.
32. Zhao Keming, Guan, Xu Kehua, Dong Yubin *, Tang Bo *. A dye-sensitized FeOOH-CNT photocatalyst has three electron transfer channels controlled by hydrogen bonds. Application directory. B: Nearby. , 20 13, 136- 137, 334-340. 1, Shandong provincial science and technology department project: synthesis of new and efficient pesticides and pharmaceutical intermediates, identified in 2003, and the achievement level is internationally leading.
2. Shandong Science and Technology Department Project: Study on the Intermediate of Trifluoromethyl Salicylic Acid, which was identified in 2003, and the achievement level is leading internationally.
3. Shandong Provincial Science and Technology Department Project: A new process for the production of nitrile and ketone pesticides and pharmaceutical intermediates by fixed bed catalysis, which passed the appraisal in 2003 and the achievement level is leading internationally.
4. Project of Shandong Provincial Department of Education: The synthesis of 2- hydroxy -4- trifluoromethylbenzoic acid, an intermediate of high efficiency and low toxicity medicine and pesticide, passed the appraisal in 2003, and the achievement level is leading internationally.
5. Funding plan for key teachers in colleges and universities of the Ministry of Education: Research and application of new dual-band light energy conversion thin film materials, which passed the appraisal in 2004 and the achievement level is advanced internationally.
6. Jinan Youth Science and Technology Star Program: Strengthen the research and application of new materials for crop photosynthesis, passed the appraisal in 2004, and the achievement level reached the international advanced level.
7. Development projects of Shandong Science and Technology Development Plan: pilot production of composite, single-core and dual-band light energy conversion materials and research and development of new products of ecological shed film, reaching the international advanced level. 2007
8. Key scientific and technological project of Shandong Science and Technology Department: Research and application of clean production process of electrochemical synthesis of fluorine-containing intermediates with international leading level. 2007
9. Key project of Shandong Provincial Department of Education: Study on the new green production process of trifluoromethylaniline, a pharmaceutical intermediate with international advanced level. 2007
10. The development of bionic light energy conversion materials for regulating photosynthesis and its application in crop planting are in the leading position in the world. In 2008, I developed and put forward the theoretical model of green chemical industry and innovative production technology.
Trost's theory of atomic utilization is developed, and a theoretical model of effective value of atomic utilization is put forward, which is applied to the production of fertilizers and fine chemicals with serious pollution discharge. More than 40 kinds of products have established new cleaner production technologies, which have minimized the discharge of pollutants from the source. 1. Study on new technology of producing ternary compound fertilizer of nitrogen, phosphorus, potassium, sulfur or chlorine by direct method of phosphate rock powder.
A new process for producing nitrogen, phosphorus, potassium, sulfur or chlorine-based ternary compound fertilizer directly from phosphate rock powder was developed. This technology solves the environmental pollution caused by the accumulation of phosphogypsum in the traditional production process, and the effective value of atomic utilization rate reaches 100%, which has become a model of clean production technology of compound fertilizer. The accumulated output value was 654.38+0.83 billion yuan, and the profits and taxes were 654.38+0.80 billion yuan, which produced remarkable economic and social benefits. 200 1 won the second prize of national science and technology progress and the first prize of Shandong science and technology progress. The implementation of this project, to a certain extent, solved the problem that China relied on imports for high-quality NPK compound fertilizer at that time, greatly promoted the development of compound fertilizer industry, and increased crop output and farmers' income. Linyi, Shandong Province, where the project is implemented, has become a national compound fertilizer production base. Professor Tang Bo won the Labor Medal of "Enriching the People and Prospering Shandong" and "Excellent Professional and Technical Talents" in Shandong Province, and became the first batch of young and middle-aged experts with outstanding contributions in Shandong Province. 2. Research on the integration of green chemical production technology of important pesticides and pharmaceutical intermediates. Professor Tang Bo's research group completed the clean production of 38 important pesticides and pharmaceutical intermediates by developing new catalysts and reaction AIDS with high activity and long life, and applying new clean electrosynthesis technology, which maximized the effective value of atomic utilization rate and controlled the environmental pollution caused by the production process. By 2006, the cumulative output value reached 365.438 billion yuan, and the profits and taxes reached 60 million yuan. The implementation of this project has played a good demonstration role for the clean production of fine chemicals and achieved remarkable economic and social benefits. This achievement won the first prize of scientific and technological progress in Shandong Province in 2004, the second prize of national scientific and technological progress in 2006, the second prize of technological invention in Shandong Province, the special prize of invention and entrepreneurship in Shandong Province in 2007 and the third national invention and entrepreneurship award. Professor Tang Bo was awarded the title of "Advanced Worker in Shandong Province" in 2007. The second is to apply the "light ecology" new shed film to agricultural production and realize modern ecological agriculture. According to the principle of plant photosynthesis, a new type of "photo-ecological" greenhouse film was developed to reduce the use of pesticides and fertilizers in agricultural production, improve the quality of agricultural products, achieve the effect of increasing production and income, and solve the problems of single light emission, low light transmittance and limited popularization and application caused by high production cost. 20 10 this product has been popularized and applied in Shandong, Anhui, Henan, Shanxi and other places all over the country, with an accumulated crop planting area of more than 40,000 mu and an agricultural product income of 600 million yuan. According to the calculation of increasing production 15%, farmers' income increased by 90 million yuan, which has achieved remarkable economic and social benefits, and is of great significance for increasing farmers' income, promoting agriculture through science and technology, developing low-carbon economy and realizing ecological agriculture. This achievement won the gold medal of "Yizeng Engineering Cup" in Shandong Province and the second prize of Shandong Patent Award. 20 10, the project won the first prize of technological invention in Shandong province. Synthesis and application of molecular and nano fluorescent probes for biological imaging
Committed to the research of new practical molecules and nano-fluorescent probes, and applied the results to the imaging detection of many important life-related substances in cells and living tissues. Related research results have been published in world-renowned comprehensive chemical journals such as J.Am.Chem.Soc, which has attracted wide attention from colleagues at home and abroad. The research results have been cited by the American Chemical Society, Chemical Review, Proceedings of the American Academy of Sciences, international editors of chemistry, advanced materials and other famous journals. Many scientific research institutions, such as Hopkins University, Tokyo University, Forest Products Laboratory of the US Department of Agriculture, France, Germany, etc., have written to ask for synthetic probes. This research achievement won the first prize of Shandong Natural Science in 2008. Instructed more than 0/0 postdoctoral students, trained more than 4 doctoral students and 90 master students. Among the graduate students, 5 papers were selected as outstanding master's theses in Shandong Province, and 1 won the first prize of outstanding scientific research and innovation achievements of the first graduate students in Shandong Province in 2006. Many people have been admitted to Georgia State University, Virginia Tech, National University of Singapore, Tsinghua University, Peking University, Chinese Academy of Sciences, Nankai University, Nanjing University or engaged in postdoctoral research. In 2006, he was awarded the first excellent postgraduate tutor in Shandong Province.
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