Bisoprolol Fumarate Tablets
Adverse reactions 1. Mild fatigue, chest tightness, dizziness, bradycardia, drowsiness, palpitations, headache and lower limb edema may occur in the early stage of taking the drug. etc., will automatically reduce or disappear after continuing to take the medicine. 2. In rare cases, gastrointestinal disorders (diarrhea, constipation, nausea, abdominal pain) and skin reactions (such as erythema, itching) may occur. 3. Occasionally, blood pressure drops significantly, pulse is slow, or atrioventricular conduction disorders occur. 4. Sometimes a tingling sensation or cold limbs may occur. In rare cases, it may lead to muscle weakness, painful muscle spasms and less tears. 5. For patients with intermittent claudication or Raynaud's phenomenon, the condition may be aggravated in the early stage of taking the drug, and the condition of patients with original myocardial insufficiency may also be aggravated. 6. Increased airway resistance occasionally occurs. 7. For elderly patients with diabetes, their glucose tolerance may be reduced and symptoms of hypoglycemia (such as rapid heartbeat) may be masked.
Contraindications 1. Shock, atrioventricular conduction disorder (second and third degree atrioventricular block), sick sinus syndrome, sinoatrial block, bradycardia (below 50/min), Hypotension, bronchial asthma and advanced peripheral circulation disorders. 2. For adrenal tumors (pheochromocytoma), this product can only be taken after using α-receptor blockers.
Notes 1. Diabetics and patients with acidosis who have large fluctuations in blood sugar concentration should take it with caution. 2. Use with caution in patients with pulmonary insufficiency and severe liver and kidney insufficiency. 3. When discontinuing treatment, the dose should be reduced day by day, and the dose should often be reduced when combined with other antihypertensive drugs. 4. If overdose causes slow heartbeat or low blood pressure, you must stop taking this product. When necessary, the following drugs can be used alone or continuously: atropine 0.5 mg ~ 2.0 mg intravenously, propastamine slow intravenous injection in appropriate amounts; glucagon 1 mg ~ 5 mg (or 1 mg ~ 10 mg). 5. Due to the antihypertensive effect of this product, it may weaken the patient's ability to drive or operate machinery, especially when taking it for the first time or when switching drugs, or when taking it with alcohol, but it will not directly affect a person's reaction ability.
The brand name of Losartan Potassium and Hydrochlorothiazide Tablets is "Haijia"
Adverse reactions
In the clinical trials of Losartan Potassium and Hydrochlorothiazide, no observations were made specific adverse reactions to this combination preparation. Limited to previously reported adverse reactions to losartan potassium and/or hydrochlorothiazide. The overall incidence of adverse reactions was similar to placebo. The percentage of treatment discontinuations was also similar to placebo.
In general, losartan potassium-hydrochlorothiazide is well tolerated. The vast majority of adverse reactions are mild and transient and do not require interruption of treatment.
In controlled clinical trials of losartan potassium-hydrochlorothiazide in the treatment of essential hypertension, dizziness was the only reported drug-related adverse reaction with an incidence rate greater than 1 or higher and higher than placebo.
Other adverse reactions discovered after marketing:
Hypersensitivity: Angioedema (including laryngeal and glottis edema leading to airway obstruction and/or Swelling of the face, lips, pharynx, and/or tongue) has been reported; some of these patients had experienced angioedema from other medications (such as ACE inhibitors). Vasculitides, including Henoch-Schoenlein purpura, have also been rarely reported with losartan therapy.
Digestive tract: Hepatitis has been rarely reported in patients treated with losartan. Diarrhea.
Respiratory tract: Losartan has been reported to cause cough.
Skin: Urticaria.
Laboratory findings: In controlled clinical trials, clinically important changes in clinically important standard laboratory indicators were rarely related to the use of this product. Hyperkalemia (serum potassium >5.5 mEq/L) occurred in 0.7% of patients, but in these trials, there was no need to discontinue this product. ALT elevation rarely occurred and usually recovered after discontinuing this product.
The following are the adverse reactions of Losartan and Hydrochlorothiazide when used alone, so they may also be potential adverse reactions of this product.
Losartan rash, dose-related orthostatic hypotension, abdominal pain, weakness/fatigue, chest pain, edema, swelling, palpitations, tachycardia, indigestion, nausea, back pain, muscle cramps, Headache, insomnia, cough, nasal congestion, pharyngitis, sinus disorders, upper respiratory tract infection, migraine, liver function abnormalities, anemia, myalgia, itching.
Hydrochlorothiazide anorexia, gastrointestinal irritation, nausea and vomiting, cramps, diarrhea, constipation, jaundice (jaundice caused by intrahepatic bile accumulation), pancreatitis, sialadenitis, dizziness, paresthesia, headache, yellow vision leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, purpura, photosensitivity, fever, necrotizing vasculitis (vasculitis) (cutaneous vasculitis), respiratory distress (including pneumonia) and pulmonary edema), toxic epidermal necrosis and laxity, hyperglycemia, glycosuria, hyperuricemia, electrolyte imbalances including hyponatremia and hyperkalemia, renal dysfunction, interstitial nephritis, renal failure, muscle cramps, weakness, restlessness, Momentary blurred vision.
Contraindications
Patients who are allergic to any ingredients of this product.
Patients with anuria.
Patients allergic to other sulfa drugs.
Precautions
Losartan-Hydrochlorothiazide
Allergic reaction: angioedema (see Adverse Reactions)
Liver function and kidney Functional impairment: Patients with hepatic insufficiency or severe renal insufficiency (creatinine clearance ≤30ml/min) are not recommended to use this product (see usage and dosage)
Losartan
Kidney Insufficiency: Inhibition of the renin-angiotensin system can lead to changes in renal function. Renal failure has been reported in individual sensitive patients (especially in some diseases where renal function depends on the renin-angiotensin-aldosterone system, such as Patients with severe cardiac insufficiency or renal dysfunction). In some patients, changes in kidney function can be reversed after treatment is discontinued.
It has been reported that anemia occurs in some patients with severe kidney disease or kidney transplants when treated with losartan potassium.
In patients with bilateral or unilateral renal artery stenosis or renal artery stenosis in a single kidney, the use of other drugs that affect the renin-angiotensin system can cause an increase in plasma urea and creatinine; losartan Similar effects have also been reported. These changes in renal function may be reversed by discontinuation of the drug.
Hydrochlorothiazide
Hypotension and electrolyte imbalance: As with all other antihypertensive treatments, some patients may develop symptomatic hypotension, and patients should be observed for diarrhea or vomiting. Clinical signs of water or electrolyte imbalance, such as hypovolemia, hyponatremia, hypochloremic alkalosis, hypomagnesemia, or hypokalemia. Blood electrolytes should be checked regularly.
Effects on metabolism and endocrinology: Treatment with thiazides can impair glucose tolerance. The dose of antidiabetic agents, including insulin, may need to be adjusted (see Drug Interactions).
Thiazides can reduce urinary calcium excretion and cause intermittent mild elevations in blood calcium. Marked hypercalcemia may be a sign of latent hyperparathyroidism. Thiazides should therefore be discontinued before performing parathyroid function measurements.
Elevated cholesterol and triglycerides may be associated with thiazide diuretic treatment.
Thiazide therapy may precipitate hyperuricemia and/or gout in some patients. Because losartan lowers uric acid, the combination of losartan potassium and hydrochlorothiazide may reduce diuretic-induced hyperuricemia.
Others: Regardless of whether the patient has a history of allergies or bronchial asthma, allergic reactions may occur when taking thiazide drugs. Cases of exacerbation or exacerbation of systemic lupus erythematosus have been reported with the use of thiazides.