Escitalopram acts on serotonin 1-7 receptors or other receptors including alpha and beta adrenergic, dopamine 1-5, histamine 1, muscarinic acid 1-5 and benzodipine. Azepine receptors have no effect or are very small, and have no effect on Na+, K+, Cl- and Ca++ ion channels. In the treatment of severe depression, the starting dose is 10 mg once a day, which can be increased to 20 mg once a day after one week, taken orally in the morning or evening. Treatment should generally last several months or even longer. No dose adjustment is required in patients with mild or moderate renal impairment. Use with caution in patients with severe renal insufficiency. After multiple administrations, the elimination half-life of Escitalopram Oxalate Tablets is about 30 hours, and the plasma clearance rate (Cloral) of the oral drug is about 0.6L/minute. The half-life of the main metabolite of the drug is longer, and Escitalopram Oxalate Tablets have a longer half-life. Thalopram tablets (Lacepro) and its metabolites are mainly eliminated by the liver (metabolism) and kidneys, and are mainly excreted in the urine in the form of metabolites. Prolonged half-life of citalopram and mildly elevated plasma drug concentrations (CLCR 10-53 ml/min) were observed in patients with reduced renal function. Plasma concentrations of metabolites have not been studied but may be elevated. Therefore, if people with poor kidney function take Escitalopram Oxalate Tablets, it may increase the burden on the kidneys. Especially for people with severe renal insufficiency, it is recommended to consult a doctor before use. Kangaiduo Pharmacy reminds you: For your health, please take medicine on time and in the right amount as directed by your doctor. If you have any questions about medication, you can consult the pharmacy customer service of Kangaiduo Pharmacy for better answers and help.