The difference between the two lies in the origin and wine style, variety and taste, price and grade.

1. Origin and type of wine: Grange Penfolds is located in Aberdeenshire in northeastern Scotland. It is famous for its exquisite Highland whiskey with aromas of orange, honey and vanilla. Penfolds is based in Australia and is loved for its fruity red and white wines.

2. Variety and taste: Grange and Penfolds usually focus on its Highland whiskey series, which usually have exquisite taste and unique aroma. Penfolds mainly focuses on wine, including the famous Penfolds Grange, which is known as the King of Australian Wine and is highly praised at home and abroad.

3. Price and grade: Penfolds Grange is considered to be of very high quality. It is of the same grade as Lafite red wine, and its market price is relatively high. The price and grade of Grange Penfolds may be relatively low.