Edit the properties of this paragraph.
Colorless volatile fuming liquid, similar to acetic acid, with hygroscopicity and pungent smell. It is miscible with water, fluorinated hydrocarbons, methanol, ethanol, ether, acetone, benzene, carbon tetrachloride and hexane, and can partially dissolve carbon disulfide and alkanes with more than six carbons. It is an excellent solvent for protein and polyester. Due to the influence of electron-withdrawing trifluoromethyl, it is strongly acidic. Its acidity is stronger than acetic acid100000 times.
It can be reduced to trifluoroacetaldehyde and trifluoroethanol by sodium borohydride or lithium aluminum hydride. It is stable above 205℃, and ester and amide derivatives are easily hydrolyzed, so it can be used to prepare sugar, amino acid and peptide derivatives in acid or anhydride form. It is easy to dehydrate into trifluoroacetic anhydride under the action of phosphorus pentoxide and decompose into fluoroacetic anhydride and carbon dioxide in the presence of aniline.
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Trifluoroacetic acid has many preparation routes:
1, 3,3,3-trifluoropropene was oxidized by potassium permanganate.
2. Acetic acid (or acetyl chloride and acetic anhydride) is electrochemically fluorinated with hydrofluoric acid and sodium fluoride, and then hydrolyzed.
3,3,3-trichloropropene was oxidized by potassium permanganate. This raw material can be prepared by tungsten fluorination of hexachloropropene.
4. It is prepared by oxidizing 2,3-dichlorohexafluoro -2- butene.
5. trifluoroacetonitrile is formed by the reaction of trichloroacetonitrile and hydrogen fluoride, and then hydrolyzed.
6. It is obtained by the oxidation of trifluorotoluene.
The purpose of editing this paragraph
It is used as a solvent, a raw material for preparing organic fluorine compounds (pesticides, dyes and chemical reagents), a catalyst for esterification, polymerization and condensation, a protective group for hydroxyl and amino groups, and also used for removing the protective group of t-butoxycarbonyl (t-boc) of amino acids in polypeptide synthesis.
As an inorganic acid, trifluoroacetic acid has good solubility and strong acidity. When used with carbon disulfide, it can dissolve protein.
Sometimes, a salt of trifluoroacetic acid can be used. At room temperature, mercuric acetate trifluoride can mercurize fluorobenzene (electrophilic substitution) or convert hydrazone into diazo compound. The lead salt of this acid can convert aromatic hydrocarbons into phenol.