http://www.ncbi.nlm.nih.gov/ can query the gene protein sequence. You can also search some literature.

The most important website in molecular biology. Without it, many things would become very troublesome, such as comparison and query of homologous genes.

The following is an introduction: http://www.biosino.org/pages/ncbi-1.htm

Introduction to NCBI (National Center for Biotechnology Information)

Introduction

Understanding the natural silent but subtle language of living cells is a requirement of modern molecular biology. Through an alphabet with only four letters representing the chemical subunits of DNA, a grammar emerged for the processes of life, the most complex of which is human beings. Elucidating and using these letters to form new "words and phrases" is a central focus in the field of molecular biology. The vast amounts of molecular data and the mysterious and sophisticated patterns of these data make computerized databases and analysis methods an absolute necessity. The challenge is to find new ways to handle the volume and complexity of these data, and to provide researchers with better access to analytical and computational tools to advance understanding of our genetic heritage and its role in health and disease. .

Establishment of the National Center

Later Senator Claude Pepper realized the importance of information computerization process methods in guiding biomedical research and initiated the establishment of the National Center on November 4, 1988. National Center for Biotechnology Information (NCBI) legislation. NCBI is a division of the National Library of Medicine (NLM) at the NIH. NLM was selected for its experience in creating and maintaining bioinformatics databases and its ability to establish an in-house research program in computational molecular biology. NCBI's mission is to develop new informatics technologies to aid the understanding of the fundamental molecular and genetic processes that control health and disease. Its mission includes four tasks:

Establish automated systems for the storage and analysis of knowledge about molecular biology, biochemistry, and genetics

Implement important information for analyzing biology Advanced methods for computer-based information processing of the structure and function of molecules and complexes

Accelerate the use of databases and software by biotech researchers and medical therapists.

A worldwide cooperative effort to collect biotechnology information.

NCBI implements its four programs through the following programs:

Basic Research

NCBI has a multidisciplinary research team including computer scientists, molecular biology Scientists, mathematicians, biochemists, experimental physicists, and structural biologists focus on basic and applied research in computational molecular biology. These researchers not only make important contributions to basic science, but also often become the source of new methods for applied research activities. Together they use mathematical and computational methods to study fundamental biomedical problems at the molecular level. These problems include gene organization, sequence analysis, and structure prediction. Some representatives of current research programs are: detection and analysis of genetic organization, repeat sequence forms, protein domains and structural units, creation of a genetic map of the human genome, mathematical modeling of the dynamics of HIV infection, analysis of the impact of sequence errors in database searches, development New database search and multiple sequence alignment algorithms, building non-redundant sequence databases, mathematical models for statistical significance assessment of sequence similarity, and vector models for text retrieval. In addition, NCBI researchers also insist on promoting cooperation with other institutes within the NIH and many academies and government research laboratories.

Databases and Software

In October 1992, NCBI assumed responsibility for the GenBank DNA sequence database. NCBI staff with advanced training in molecular biology built the database from sequences submitted by various laboratories and by exchanging data with international nucleic acid sequence databases (EMBL and DDBJ). Arrangements with the U.S. Patent and Trademark Office allow patent sequence information to be integrated.

GenBank is the NIH Genetic Sequence Database, an annotated collection of all publicly available DNA sequences.

GenBank has formed an international nucleic acid sequence database collaboration with the DNA databases of Japan and the European Molecular Biology Laboratory. The three organizations exchange data on a daily basis.

GenBank is growing exponentially, with the number of nucleic acid bases doubling approximately every 14 months. Recently, GenBank held 3 billion bases from 47,000 species.

Mendelian Inheritance in Man (OMIM), Molecular Model Database of Three-Dimensional Protein Structure (MMDB), Unique Human Gene Sequence Collection (UniGene), Human Genome Gene Map, Taxonomy Browser, with the National Cancer Institute Collaborative Cancer Genome Profiling Project (CGAP).

Entrez is NCBI's search and retrieval system that provides users with integrated access to sequence, location, classification, and structural data. Entrez also provides graphical views of sequences and chromosome maps. Entrez is a search and retrieval tool for integrating information from NCBI databases. These databases include nucleic acid sequences, protein sequences, macromolecular structures, whole genomes, and MEDLINE searched through PubMed. A powerful and unique feature of Entrez is the ability to search related sequences, structures, and references. Journal literature was obtained through PubMed, a web search interface that provides access to nine million journal citations on MEDLINE and contains links to full-text articles at participating publisher web sites.

BLAST is a sequence similarity search program developed by NCBI and can also be used as a means to identify genes and genetic characteristics. BLAST is capable of performing sequence searches of entire DNA databases in less than 15 seconds. Additional software tools provided by NCBI include: open reading frame finder (ORF Finder), electronic PCR, and sequence submission tools, Sequin and BankIt. All NCBI databases and software tools are available from the WWW or FTP. NCBI also has an e-mail server that provides an alternative method of accessing the database using text search or sequence similarity search.

Education and Training

NCBI fosters scientific communication in the field of computing with applications to molecular biology and genetics by sponsoring conferences, workshops, and lecture series. A scientific visiting scholar program has been established to foster collaboration with external scientists. As part of the research program within NIH, postdoctoral positions are also available.

http://www.ncbi.nlm.nih.gov/About/index.html

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