Properties: This product is a white or off-white suspension, which should be evenly dispersed after shaking. Observed under a microscope, the crystals are rod-shaped, and the vast majority of the crystals must not be less than 1 μm or larger than 60 μm, and no aggregates exist.

Pharmacological Toxicity This product is human insulin produced using recombinant DNA technology and has the same structure and function as natural insulin. It can regulate glucose metabolism, promote the uptake and utilization of glucose by the liver, bones and adipose tissue, promote the conversion of glucose into glycogen and store it in muscles and liver, and inhibit gluconeogenesis, thereby lowering blood sugar. Pharmacokinetics: Due to individual differences in subcutaneous injection of this product, the onset and duration of the drug vary greatly. Generally, the onset of action is slow after injection, reaching a peak in 6 to 9 hours, and lasting for about 24 hours.

Pharmacokinetics

Indications: Diabetes.

Usage and Dosage 1. This product is a white suspension and should be injected subcutaneously about 1 hour before breakfast or dinner. The specific time is determined by the doctor based on the condition. 2. How to prepare insulin: Be careful not to let the needle come into contact with anything during use to prevent contamination. If it needs to be mixed with regular recombinant human insulin injection, it should be done under the guidance of a doctor. Before withdrawing protamine recombinant human insulin, the vial should be placed in the palms of both hands and rolled gently until the insulin becomes a uniform suspension. Use a syringe to extract the required amount of air for protamine recombinant human insulin and inject the air into it. Protamine recombinant human insulin bottle, and then pull out the needle. Then use a syringe to extract the same amount of air required to inject regular recombinant human insulin, and inject the air into the bottle of regular recombinant human insulin. Then turn the bottle and syringe upside down, extract the correct dose of regular recombinant human insulin, and remove the air bubbles in the syringe. Drain and check that the dose is correct. Then insert the needle into the vial of protamine recombinant human insulin, draw out the specified dose of insulin, remove the air bubbles, and check whether the dose is correct. The insulin should be withdrawn in this order for each injection and the mixture should be injected immediately.

Adverse reactions reported in the literature include occasional local redness, swelling, itching and other allergic reactions as well as local subcutaneous lipid hyperplasia. Systemic allergic reactions (body rash, shortness of breath, wheezing, decreased blood pressure, rapid pulse, excessive sweating, and life-threatening in severe cases) have been rarely reported. 1. Lipodystrophy: Subcutaneous injection of insulin rarely causes lipid atrophy or lipid hyperplasia. If the above happens, you must inform your doctor. Changing the injection technique may improve this. 2. Insulin allergy: ① Local allergic reaction. Patients occasionally experience redness, swelling and itching at the injection site, which is called local allergy. This usually disappears within a few days or weeks. In some cases, it may be caused by other reasons unrelated to insulin injection. If there is any local reaction such as skin disinfectant irritation or poor injection technique, please inform the doctor immediately. ② Systemic allergic reaction. This chance occurs rarely, but once it occurs, the condition is serious. It is a systemic allergy to insulin. Symptoms include: body rash, shortness of breath, asthma, decreased blood pressure, rapid pulse, sweating, and severe cases can be life-threatening.

Contraindicated for those with a history of insulin allergy.

Notes 1. Diabetic patients should check their blood sugar or urine sugar regularly. If the blood sugar test continues to be higher or lower than the normal value or the urine sugar continues to be positive, it means that the diabetes is not properly controlled, and the doctor must be notified frequently. Keep enough insulin, as well as syringes and needles, and wear your diabetes identification badge regularly to ensure proper treatment if complications occur away from home. 2. Any changes in insulin application must be done with caution and under the guidance of a doctor. Before each use of insulin, you should carefully check whether the purity, potency, registered trademark, type, species (cow, pig, human), and production method (recombinant human insulin, animal-purified insulin) of insulin are recommended by your doctor. Changes in any of the above items will result in changes in dosage. 3. Patients who used animal insulin in the past must adjust the dosage under the guidance of a doctor when switching to this product. 4. Before taking the medicine, you should carefully check whether the bottle cap is intact, and carefully check the name and letter mark on the bottle label to confirm that the medicine you take is consistent with the doctor's prescription. 5. Before extracting the liquid, check the appearance of the contents in the bottle. The protamine recombinant human insulin injection should be a white or off-white suspension. If there is still sediment at the bottom of the bottle after shaking, or there are lumps of floating matter cut into pieces. Do not use and consult your doctor immediately if you notice any abnormalities or if you need to change your insulin dose. 6. When mixing two types of insulin, it must be done under the guidance of a doctor.

Note that syringes and needles from different manufacturers may not match. Be careful not to change the order of withdrawing insulin, and do not arbitrarily change the syringe and needle types recommended by your doctor. 7. Insulin should be stored in the refrigerator at 2 to 8°C. Do not freeze or approach the ice tray. Frozen insulin cannot be used. Do not use insulin that has exceeded the expiration date. If the protective cover of the purchased medicine is not tight, be sure to remove it. To be returned to the pharmacy. 8. Disposable syringes must not be reused, and needles and syringes must not be used with others. Reusable syringes must be sterilized before use (normally, they can be sterilized by boiling, and when traveling, use 91% isopropyl alcohol. Disinfection is easier).

Pregnant and lactating women taking medication during pregnancy can make diabetes more difficult to control. Therefore, female patients of childbearing age who are planning to become pregnant and who are pregnant or lactating must consult a doctor.

Children should pay attention to the amount of exercise and diet when using this medicine to better control blood sugar. When used, parents or doctors should inject according to the dose adjusted by the doctor.

Elderly patients take medication. The structures and functions of various tissues and organs of elderly patients change. Physiological and biochemical reserve capacity decreases, and regulatory function and adaptability decrease. More attention should be paid when using this product. 1. Lesions of the adrenal gland, pituitary gland, thyroid and other diseases or worsening of liver and kidney diseases can easily cause hypoglycemia. 2. Forgetting or postponing meals can easily cause hypoglycemia. 3. If necessary, a dedicated person can control each dosage and injection operation.

Drug Interactions Oral contraceptives, adrenocortical hormones, thyroid hormone replacement therapy, etc. will cause an increase in blood sugar, and the dose of insulin should be increased when used at the same time. Oral antidiabetic agents, salicylates, sulfonamides, and certain antidepressants can cause a drop in blood sugar. The dose of insulin should be reduced during concurrent use. Avoid alcoholic beverages.

Drug Overdose During insulin treatment, if too much insulin is used, a hypoglycemic reaction may occur. Symptoms of mild to moderate hypoglycemia may occur suddenly. The main symptoms are sweating, dizziness, palpitations, tremors, hunger, weakness, tingling in hands, feet, tongue, lips, dizziness, lack of concentration, headache, drowsiness, insomnia, anxiety, blurred vision, slurred pronunciation, and depression. , irritability, abnormal behavior, unstable behavior, personality changes, etc. Symptoms of severe hypoglycemia include disorientation, loss of consciousness, epilepsy, and death. It is important to get prompt treatment when hypoglycemia occurs. In some cases, the early symptoms of hypoglycemia are not easy to detect. For example, long-term diabetic patients, diabetic patients with neuropathy, diabetic patients using beta-blockers, patients who change insulin preparations, and patients who receive intensive insulin therapy (receiving 3 or more insulin injections per day) . A small number of patients will experience hypoglycemic reactions when converting animal-derived insulin to human insulin. At this time, the early hypoglycemic reactions are difficult to detect and are different from previous hypoglycemic reactions. If you cannot detect the early symptoms of hypoglycemia, it will be unavoidable. Severe hypoglycemic reaction. To be alert to the occurrence of hypoglycemia symptoms, blood glucose concentrations must be monitored frequently. Mild to moderate hypoglycemia can be corrected by eating or drinking sugary drinks. More severe hypoglycemia requires care. At this time, the patient may lose consciousness and be unable to eat on his own, and needs glucagon injection, or intravenous glucose injection if medical conditions permit. Patients must learn to recognize the symptoms of hypoglycemia in themselves, and if they are unsure of these symptoms, learn to recognize the symptoms of hypoglycemia by closely monitoring their blood sugar. If hypoglycemia occurs frequently and the symptoms are not easy to detect, you must seek medical advice and discuss with your doctor whether to change your treatment plan, diet and exercise plan to avoid the occurrence of hypoglycemia.

Specification: 1000u/10ml/bottle

Packaging: 1 bottle/box

Storage: 2℃-8℃, protected from light, do not freeze. Once used, it can be stored for 28 days at a temperature not higher than 25°C. It is strictly prohibited to use it after the expiration date.

Valid for 24 months

Imported drug registration certificate number Imported drug repackaging approval number