In recent years, there are many kinds of fishery drugs, which make users feel at a loss when choosing. In this paper, the packaging, product appearance and "three certificates" of fishery drugs are expounded, so as to provide reference for users when choosing fishery drugs.
First, check the packaging.
1. Veterinary drug products (except APIs) must use both the inner packaging label and the outer packaging label. The label of the inner package must indicate the "veterinary drug" logo, the name of the veterinary drug, indications (or functional indications), contents/packaging specifications, production license number, approval number or registration certificate number of imported veterinary drugs, production batch number, expiration date, information of the production enterprise (enterprise name, address and contact information), etc. The outer packaging label must indicate the animal identification, veterinary drug name, main ingredients, indications (or functional indications), usage and dosage, contents/packaging specifications, production license number, approval number or certificate number of imported veterinary drug registration license, production batch number, validity period, drug withdrawal period, storage and packaging quantity, and information of production enterprises.
2. Check the registered trademark. Regular fishery drug manufacturers have applied for registered trademarks, and registered trademarks (patterns, pictures, words, etc.). ) The words "registered trademark" or "registered mark" must be marked on the packaging, labels and instructions of veterinary drugs. Fake veterinary drugs produced by illegal manufacturers often have no trademarks or use unregistered trademarks.
3, check whether the production, sale and use of fishery drugs eliminated or prohibited by the state. Exceptions: some fishery drugs have been verified for a long time, but their efficacy is not certain, some have great toxic and side effects, and some residues in aquatic products exceed the standard after use, which is harmful to human health, and so on. Conditional users can pay attention to the unqualified product sampling notice issued by official website (www.agri.gov.cn) of the Ministry of Industry and Information Technology.
Second, the visual appearance of the product.
1, powder? The outer packaging should be complete, with no obvious difference in loading capacity and no flatulence. The powder is dry and loose, with uniform particles and consistent colors, and has no peculiar smell, deliquescence, mildew, caking, stickiness and moth-eaten.
2. Water agent? Open the packaging bottle to observe that there should be no obvious difference in its loading capacity, and the container should be complete and unified without leakage. The bottle mouth should be sealed with wax, the container should be completely dissolved after adding the specified solvent, and the solution should be clear and free of foreign substances. The color of the solution should be consistent and clear, and there should be no foreign matter, precipitation or turbidity; In winter, individual products are allowed to precipitate a small amount of crystals, which should be completely dissolved after heating, otherwise abnormal phenomena such as floc may not be used.
3. tablet computer? The outer packaging should be intact, the appearance should be neat and complete, the color should be uniform, the surface should be smooth, there should be no spots and pits, and it should have appropriate hardness. Its dissolution time in water meets the product requirements after testing.
4. Chinese herbal medicine? Mainly depends on whether there is moisture absorption, mildew, moth-eaten or flatulence. , if the above phenomenon occurs, it is not suitable for continued use. The fineness of powder should meet the product requirements; If it is a Chinese herbal medicine tablet, the tablet body should be free from adhesion, dissolution and mildew, and the edge should be neat, and there should be no looseness, fragmentation, roughness and uneven thickness.
5. Injection? Any ineffective drug, injection with irregular transparency, discoloration, foreign matter, broken container or loose cork, clots after rapid stratification or shaking of suspension injection, deformation of freeze-dried product, or plant loose pieces stuck in the bottle are not suitable for use.
Third, attention: "three certificates"
1, production license? The validity period is 5 years, and you must re-apply with the original certificate within 6 months before the expiration. At the same time, the annual inspection system is implemented for production licenses. The master license shall include the license number, enterprise name, legal representative, person in charge of the enterprise, enterprise type, registered address, production address, production scope, issuing authority, issuing date, validity period and other items. An enterprise shall not produce products beyond the permitted scope. After the production license is revoked, it shall immediately stop the production and sales of products. Announcement No.202 of the Ministry of Agriculture of China stipulates that since June 5438+ 10/day, 2004, the approval number of any product will not be renewed for enterprises that have not obtained GMP certificate, and the national veterinary drug production industry must reach the good manufacturing practice (GMP) before June 5438+February 3, 2005. Therefore, if GMP is not passed, the enterprise will not be allowed to produce.
2. Approval number? The packaging of fishery drugs must have the approval number issued by the Ministry of Agriculture or the provincial animal husbandry and veterinary administrative department. Imported veterinary drugs have the Registration Certificate of Imported Veterinary Drugs issued by the Ministry of Agriculture and must be numbered according to the unified format stipulated by the Ministry of Agriculture. ① Approval number format of veterinary chemical (antibiotic) products or feed drug additives: Beijing (hereinafter referred to as issued by provinces, autonomous regions and municipalities directly under the Central Government), agricultural word (or drug additive word) XXXX (year) x (representing western veterinary drugs) XXX (provincial serial number issued by the Ministry of Agriculture and provincial veterinary drug factory number) XXX (variety number). For example, Beijing Veterinary Medicine Word (2000)X308603. It should be noted that the "Z" before the number indicates pure Chinese medicinal ingredients for veterinary use, "S" indicates biological products, "J" indicates imported raw material preparations, "F" indicates compound veterinary drugs of Chinese and western medicines, and those marked with "fen" indicate sub-packaged products (domestic or imported veterinary drugs in large packages are sub-packaged into small packages); Products produced during the trial production period of Class I and II veterinary drugs and new biological products are trial products, and the word "trial" should be added before the word "trial". ② The format of the approval number of biological products: raw material drug XXXX (year number) XX (pharmaceutical factory number) X (category number) XXX (variety number). No document number or other number may be used to replace or fraudulently use the approval document number of fishery drugs.
Fishery drug approval number is valid for 5 years. Fishery drug production enterprises shall go through the formalities of re-registration with the original examination and approval authority within 6 months before the expiration of the validity period. After the expiration of the validity period, the original approval number of fishery drugs will automatically become invalid, and fishery drug production enterprises shall not continue to produce and operate products with the original approval number. It should be pointed out that the development of fishery drugs is later than that of traditional veterinary drugs, and some of them come from traditional veterinary drugs and are managed by the Animal Husbandry and Veterinary Bureau, so the batch number of fishery drug preparations is the batch number of veterinary drugs. The batch number of fishery medicine preparation can only be obtained if it meets certain standard requirements, and the quality of fishery medicine with batch number is guaranteed to some extent.
3. Production batch number, which is a set of numbers or letters plus numbers, is used to identify the "batch number", usually the factory date of this batch of fishery drugs, and consists of two digits of production time, but there are exceptions. Some fishery drugs have an expiration date, which is calculated from the production date (based on the production batch number), and expired fishery drugs are beyond the expiration date.
Four, the identification of more than one drug
Fishery drugs with the same main component often have multiple trade names, such as fishery drug preparations with chlorine dioxide as the main component, and the trade names are Kebingwei, Junlik, Du Jun, etc., which should be allowed in business. Users should read the label carefully according to the purpose of treatment, recognize the main components and contents of the product, and then compare the similar products of the corresponding manufacturers, and finally choose the products with high quality and low price.
In fact, it is often impossible to completely distinguish fake and shoddy fishery drugs with the above methods. There are some identification methods in People's Republic of China (PRC) Veterinary Medicine Code (2000) or Fishery Medicine Manual (second edition), which can be referenced by qualified users. With the strengthening of fishery medicine management, the database of fishery medicine products is established to realize online query; Fishery drug anti-counterfeiting mark; The implementation of product quality inspection certificate will be beneficial to the identification of fishery drugs. When purchasing fishery drugs, users should also pay attention to asking for invoices and other credentials, and pay attention to saving fishery drug samples to prevent quality problems and facilitate the resolution of quality disputes.