Because of the remarkable curative effect of Wang Wudi's ancestral series of drugs, the demand of patients is increasing day by day. In order to carry forward the secret recipe handed down from ancestors, practice medicine for the benefit of the world and benefit more patients, Wang and his son opened the "Wangda Pharmacy" at No.26 Muxing Street, Kunming on 1929 (that is, in the 18th year of the Republic of China), and treated patients in the way of front shop and back factory, producing and selling the "Wanginvincible" ancestral series of drugs. Due to the emphasis on quality and honest management, it is welcomed by the majority of patients and enjoys a high reputation. According to Jiangchuan County Records, "patients are crowded". The influence of "Wang Invincible" brand has expanded rapidly, covering Yunnan, Guizhou and Sichuan, and also radiating to Southeast Asian countries such as Vietnam, Laos, Myanmar and Thailand. During this period, Wang was known as a famous doctor in Yunnan. Invincible series of bone medicines are famous for treating bones. Yunnan Baiyao is good at healing wounds and is known as the two holy medicines in orthopedics.