prepare
2-methylimidazole can be prepared by condensation reaction of glyoxal, ammonia and acetaldehyde (Debus-Radziszewski imidazole synthesis).
2-methylimidazole can also be obtained by the oxidation of 4,5-dihydro-2-methylimidazole.
use
2-methylimidazole is an intermediate of metronidazole and feed growth promoter, and also a curing agent of epoxy resin and other resins. As a medium-temperature curing agent for epoxy resin, it can be used alone, but it is mainly used as a curing accelerator for powder molding and powder coating. It is also an intermediate of metronidazole.
chemical reaction
Alkaline deprotonation of 2-methylimidazole;
2-methylimidazole can be used as a ligand to react with metal salts to obtain complexes. For example, it reacts with cadmium fluoborate to grow colorless CD (2-meim) 6 (BF4) 2 from the solution; It reacts with zinc nitrate or cobalt nitrate to obtain coordination polymers ZIF-8 and ZIF-67.
2-methylimidazole reacted with iodine and silver acetate in dichloromethane to obtain 4,5-diiodo-2-methylimidazole. It reacts with formaldehyde by heating in tetrahydrofuran to obtain methanol based on 2-methylimidazole.
Under the action of alkali, it can react with halogenated hydrocarbon by C-N coupling reaction, such as with iodobenzene, to obtain 2- methyl-1- phenylimidazole; Reacting with 1- bromobutane to obtain 1- butyl-2-methylimidazole.
toxicity
Acute toxicity: LD50:1400 mg/kg in mice; Rat (peritoneal) LD50: 480mg/kg
Because the LD50 of salt is 3000mg/kg, the acute toxicity of BPA is the same as that of salt.
Can cause skin allergic reaction.