Upper motor neuron injury
As the center of the central nervous system, the upper motor neuron's main function is to send transmission instructions to the lower motor neuron to control and dominate its activities. Performance after injury: Without the instruction of the supreme commander of the brain, the lower motor neurons had to go their own way, the demons danced wildly, the muscles of both upper limbs trembled, and the fine movements could not be completed; Spastic paralysis of both lower limbs, unable to coordinate walking.
Lower motor neuron injury
As an intermediate station, the lower motor neuron transmits the instructions of the upper motor neuron to the skeletal muscle, causing muscle contraction. Performance after injury: skeletal muscle can't accept all kinds of instructions and can't contract. The common first symptom is that the fingers are clumsy and unable to write. Then there was atrophy of the small muscles of the hand, which gradually spread to the whole upper limb. You can't do anything that depends on your upper limbs, such as eating, doing housework and taking care of yourself.
Motor nucleus damage of medulla oblongata
The motor nucleus of the medulla oblongata mainly includes glossopharyngeal nucleus, sublingual nucleus, vagus nerve nucleus and accessory nucleus. The symptoms after the injury are: first, the symptoms are atrophy of tongue muscles, fasciculation and weakness of tongue extension, and patients will choke and slur when eating; Then the muscles of palate, pharynx, larynx and mastication atrophy, which makes it difficult for patients to swallow and masticate.
Frozen people, also known as amyotrophic lateral sclerosis, motor neuron disease, Charcot's disease and Luger's disease, are caused by the injury of upper motor neurons and lower motor neurons, which leads to the gradual weakening and atrophy of muscles including the ball (the so-called ball refers to this part of the muscle dominated by the medulla oblongata), limbs, trunk, chest and abdomen.
People with gradual freezing have mild early symptoms and are easily confused with other diseases. Patients may only feel some symptoms such as weakness, muscle jumping and fatigue, which gradually progress to muscle atrophy and dysphagia, eventually leading to respiratory failure. According to clinical symptoms can be roughly divided into two types:
1, limb onset type
The initial symptoms are progressive atrophy and weakness of limbs muscles, and finally respiratory failure. The main manifestations are muscle stiffness and enhanced reflexes. Basically, muscle atrophy, weakness and muscle beating are the main reasons, and muscle atrophy usually occurs, which is distributed in the interosseous muscle between the palm and thumb. At the beginning, the muscles of the tiger's mouth will contract slowly, and then the muscles such as shoulders, neck and tongue will also contract, causing dysphagia and respiratory failure.
2. The types of medulla oblongata
When there is no problem with the movement of limbs, there is already difficulty in swallowing and speaking, and it will soon progress to respiratory failure.
The most common symptoms of gradual freezing are weakness of one or two fingers, motor dysfunction, hand muscle atrophy and hand grasping.
In progressive patients, the early manifestations are atrophy and weakness of the small muscles of one hand or both hands, and then atrophy and weakness of the muscles of forearm, upper arm and scapula belt also occur.
Patients with progressive bulbar palsy are mainly characterized by unclear pronunciation, hoarseness, dysphagia, choking in drinking water, and weakness in chewing.
Patients with primary lateral sclerosis are characterized by symmetrical weakness of both lower limbs, stiff muscles and abnormal gait.
Gradually frozen people usually do not affect vision, hearing, smell, taste and touch, nor do they affect thinking, but some cases have found that they are complicated with emotional disorders and behavioral abnormalities.
There are many symptoms of freezing people. At first, they were weak and tired easily, and their muscles gradually shrank and became weak. Later, their whole body muscles atrophied, they had difficulty swallowing, and eventually they died of weakness.
Secondly, among the frozen people, there is a famous physicist, Hawking, who died on March 14 this year, which has aroused widespread social memory and deserves our deep thought. I hope that the gradual freezing disease can make a breakthrough as soon as possible. Most of the causes are neurotoxicity of cognitive glutamate or cell membrane damage of free radical neurons.
Finally, the Chinese Medical Doctor Association has a project "Melting Frozen Hearts", which is a public welfare project to help frozen people. It is a welfare for people who are gradually freezing, which is worthy of recognition. I also hope that more social elements and enterprises will join the public welfare undertakings.
Is the patient yourself?