The Department of Hematology, Changhai Hospital affiliated to Shanghai Second Military Medical University, is a specialized center of hematology in the whole army. Has a modern laminar flow ward and advanced clinical nursing system. The research in leukemia diagnosis and treatment, autologous bone marrow and peripheral blood stem cell transplantation has reached the international advanced level. The second and third cases of unrelated peripheral blood hematopoietic stem cell transplantation in China were successfully carried out to treat leukemia. And carry out research on the diagnosis and treatment of acute severe and extremely severe radiation sickness. The main clinical features are diagnosis and treatment of malignant hematological diseases such as leukemia and lymphoma, related research and application of hematopoietic stem cell transplantation, gene therapy research of hematological diseases, pathophysiological research of erythrocyte membrane and enzymes, and diagnosis and treatment of hemolytic anemia, which ranks at the advanced level in China. ? The hematology specialty group of internal medicine was established in 1962, and the hematology department was established in 1978. In 1979, it was approved by the General Logistics Department of the People's Liberation Army as the hematology center of the whole army. At present, it is an authorized point for master's and doctor's degrees in medicine, a discipline in the National Pharmaceutical Clinical Research Base, a discipline in the post-doctoral mobile station of clinical medicine in the Second Military Medical University and one of the key disciplines in Changhai Hospital. At present, there are 46 medical teaching and research technicians, including 2 professors and chief physicians, 4 associate professors and deputy chief physicians, 1 researcher and deputy chief technician, and 1 intermediate titles. Most of the medical teaching and research personnel have doctoral or master's degrees. At present, there are 11 postdoctoral, doctoral and master students. There are 34 expanded beds and 5 advanced aseptic fluidized beds; The specialized laboratory covers an area of 44M2, with modern clinical and experimental equipment such as laminar aseptic laboratory, program-controlled cryostat, computer cytopathology influence system, blood cell separator, gel imaging system, fluorescence microscope, fluorescence inverted microscope, clinical magnetic immune cell separator, etc. The annual average outpatient volume is more than 6,5, and the number of inpatients is about 5. Treat acute and chronic leukemia, lymphoma, anemia and other benign and malignant blood diseases. Entrusted by the General Logistics Department, he held seven specialized courses and advanced specialized courses for hematology in the whole army, each of which lasted from October to 3 years, and trained a number of hematology professionals for the army and local governments, including many well-known hematology scholars in China. The new medical technologies developed in this discipline over the years mainly include: 1. Hematopoietic stem cell transplantation for malignant diseases and acute radiation sickness, such as fetal liver cell transplantation, semi-contract allogeneic bone marrow transplantation, autologous and allogeneic peripheral blood stem cell transplantation, parent-child peripheral stem cell transplantation, unrelated bone marrow transplantation and CD34+ cell transplantation; 2. Clinical study of hemophilia B gene therapy (the first case in the world); 3. Establish a relatively complete method for the determination of erythrocyte enzymopathy and erythrocyte membrane disease and the diagnosis of difficult hemolytic anemia; 4. Comprehensive treatment of acute leukemia and malignant lymphoma; 5. Diagnosis of difficult hematological diseases. Since 198, more than 5 scientific research projects have been carried out, including the national "863" high-tech project fund and the national outstanding talent fund (cooperation), the national natural science fund and the key project fund of the whole army. Since 1982, he has won more than 2 fourth prizes for military scientific and technological progress, including the second prize for national invention, the third prize for national scientific and technological progress, the first prize for scientific and technological progress in Shanghai and the military, and the second prize for military scientific and technological progress and medical achievements. Professor Xu Yue 'e, Professor Yu Pei-lin and Professor Min Bihe, who have served as the director of our department, enjoy a high reputation in the field of hematology both inside and outside the military, and have made important contributions to the construction and development of this discipline. Currently, he is the director of the department, Professor Wang Jianmin, chief physician, doctoral supervisor, the training target of "1 outstanding cross-century academic leaders" in Shanghai health system and the "scientific and technological rising star" in the General Logistics Department of the People's Liberation Army. Professor Xu Xiaoping, deputy director, deputy chief physician, and tutor for master students. As mankind enters the 21st century, all the colleagues in the hematology department of Changhai Hospital will, as always, adhere to the clinical center, teaching as the basis and scientific research as the driving force, cooperate with colleagues in the domestic hematology field, serve the patients wholeheartedly and make our due contribution to the development of hematology in China. At present, the clinical characteristics and research directions of the undergraduate course mainly include the diagnosis and comprehensive treatment of malignant hematological diseases such as leukemia and malignant lymphoma, related research and clinical application of hematopoietic stem cell transplantation, gene therapy research of hematological diseases, erythrocyte membrane and enzymes. Hematopoietic stem cell transplantation in the hematology department of Changhai Hospital for the treatment of malignant hematological diseases. Since the transplantation of fetal hepatocytes was first carried out in China in 1982, hematopoietic stem cell transplantation has made rapid progress. Autologous and allogeneic bone marrow transplantation was carried out in 1986 for the treatment of malignant hematological diseases. In 199, 2 cases of acute radiation sickness were treated by HLA-mismatched bone marrow transplantation, and 1 case was successful, which was the first case in China. Autologous and allogeneic peripheral blood stem cell transplantation was carried out in 1995, and allogeneic peripheral blood stem cell transplantation was carried out in 1997. At present, five patients have been treated. The patient, 2 years old, was diagnosed with acute lymphoblastic leukemia and underwent allogeneic peripheral blood stem cell transplantation in our hospital. The donor was his sister, and HLA was a little incompatible. After transplantation, severe acute graft-versus-host disease occurred. After active treatment, his condition was controlled and he survived without disease at present. This is the first case of HLA-mismatched peripheral blood stem cell transplantation in China. In 1998, the allogeneic peripheral blood stem cell transplantation with incomplete HLA matching between parents and children was first carried out in Shanghai, and it was successful. In the same year, unrelated donor bone marrow transplantation was carried out to treat malignant hematological diseases, and 6 patients were treated. Ding Jian, a student of Fudan University who was widely concerned by the media, underwent unrelated donor bone marrow transplantation in our hospital because of chronic myeloid leukemia. At present, the hematopoietic function has basically recovered and the situation is good. Purified autologous peripheral blood CD34+ cell transplantation to treat malignant hematological diseases was carried out in our hospital in 1999. And successfully treated multiple myeloma, lymphoma and other diseases. Liberation Daily, Wen Wei Po, Health News, People's Liberation Army Daily and other media rushed to report, which had a wide social impact. This year, unrelated donor allogeneic peripheral blood stem cell transplantation was carried out in our hospital, and 2 patients were successfully transplanted. Hematopoietic stem cell transplantation not only treats acute and diffuse leukemia, but also treats myeloma, lymphoma, acute aplastic anemia and other diseases. Up to now, 8 cases of hematopoietic stem cell transplantation and 4 cases of allogeneic peripheral blood stem cell transplantation have been carried out, with a success rate of over 9% and a two-year survival rate of about 75%, reaching the international level.