Editors of the fifth, sixth and seventh sessions of Journal of Pharmacology (SCI included in SCI), invited registered reviewers of European Journal of Pharmacology (SCI included), invited registered reviewers of Journal of Toxicology (SCI included in SCI), editorial board of China Journal of Pharmacotoxicology and editorial board of Journal of Zhejiang University (medical edition). Stem cell biology and regenerative medicine/drug discovery;
Pharmacological mechanism and new drug research of cardiovascular and cerebrovascular diseases and liver;
Study on drug toxicology based on system biology. 2009-20 1 1: National Natural Science Foundation's major research plan "Compound Library Construction and Molecular Event Discovery Based on Signal Transduction Induced by ES Cells" (№ 908 13026, special research project of signal transduction based on chemical small molecular probes-cultivation project, co-leader).
2007-2009: National Natural Science Foundation Project "Microsomal GST Expression Profile of Liver Tissue System Derived from Embryonic Stem Cells and Its Drug Regulation Characteristics" (№ 30672564, project leader);
2007-2009: Research and development of five new anti-Alzheimer's drugs, a key project in the 11th Five-Year Plan of Zhejiang Province (№2006C 13075, project chief);
2005-2007: National Natural Science Foundation Project "Leukotriene paracrine/autocrine loop mediated by liver membrane protein mGST and its drug regulation" (№30472 1 12, project leader);
2005-2006: The Tenth Five-Year National Key Scientific and Technological Project "Study on the Basic Problems of Efficacy and Safety of Traditional Chinese Medicine" participated in the mechanism research of "Demonstration Study on Safety Evaluation of Chinese Patent Medicines Containing Aristolochic Acid";
2004-2006: Ministry of Commerce aided Indonesia's natural medicinal plants research and development project "Screening of active ingredients for protecting liver and resisting diabetes and research and development of new drugs" (ContractNo. (2004) Waichengzi No.020, sub-project leader);
2003-2006: The Sino-German Science Fund Project of National Natural Science Foundation "Study on the Application of Flavonoids and Related Polyphenols Active Components in Vegetables to Disease Control in China" [National Natural Science Foundation -DFG Fund №GZ05 1-3( 147), project leader];
2003-2004: The key scientific and technological project of the Ministry of Education, "Application Research on Pharmacological Screening Model of Stem Cells Differentiating into Cardiomyocytes" (№03088, project leader);
2003-2004: Zhejiang Key Scientific Research Program International Cooperation Project "Study on the Application of Embryonic Stem Cell Differentiation Cardiomyocyte Model in the Evaluation of Active Components of Traditional Chinese Medicine" (№2003C24005, project leader);
2002-2004: National Natural Science Foundation Project "Study on Intervention Effect of Drug-mediated Differentiation of Embryonic Stem Cells in Vitro" (№ 30 17 1 1, project leader);
"Separation of effective components in pollen for inhibiting prostate tumor proliferation and development of new drugs" guided by the Tenth Five-Year Plan from 2002 to 2004 (task code: 2002BA760C, project leader of the first participating unit);
200 1-2003: National Natural Science Foundation Project "Microsomal GST Modification Activation and Its Correlation with the Transformation of Exogenous Substances" (№30070904, project leader);
1999-200 1: Study on the correlation between the biological characteristics of microsomal membrane GST and the drug resistance of tumor chemotherapy (Fund for Returned Overseas Students of Ministry of Education, Foreign Affairs Department [1998] No.679);
1995- 1997: National Natural Science Foundation Project "Study on the Mechanism of Drug-induced Preimplantation Abnormality of Mammals on Fetal Development" (№39470836, project leader);
1992- 1994: National Natural Science Foundation Project "Study on the Effect of Drug-induced Preimplantation Blastocyst Abnormality on Fetal Development" (№39 170875, project leader); 1. Reactive oxygen species participate in the differentiation of mouse embryonic stem cells into cardiomyocytes induced by isopentenyl flavonoids icariin and icariin. Journal of Cell Biochemistry 2008; 103(5): 1536- 1550.
2. Zhang Yandong, Lou Yijia *, Yu Yongping *: 2,3-disubstituted 8- arylamino -3H- imidazo [4,5-g] quinazoline: a new class of anti-tumor drugs. European Journal of Medicinal Chemistry 2008; (In India, doi:10.10/6/j.ejmech.2008.01.009).
3. Zheng Ming, Qu Linhai, Lou Yijia *: Effects of Icariin combined with Panax Notoginseng Saponins on cognitive impairment and oxidative stress of hippocampal neurons and CA 1 induced by ischemia-reperfusion in rats.
Plant therapy research in 2008; 22(5):597-604.
4. Expression of *:MAPEG in mouse embryonic stem cell-derived liver tissue system. Stem cells and development 2008; 17(4):775-84.
5. Liang Xingguang, Ying Hu, Zhu, Lou Yijia p38MAPK and reactive oxygen species participate in the differentiation of mouse embryonic stem cells into cardiomyocytes induced by icariin in vitro. Stem cells and development 2008; (in printing, doi:10.1089/SCD.2007.0206).
6. Yan Bowo, Zhu, Yu Yongping, Lou Yijia *: Icariin activates NF-κB and AP- 1 to promote the heart differentiation of mouse embryonic stem cells. European journal of pharmacology. 2008; 3 1; 586( 1-3):59-66.
7. Ma Kuifen, Ye, Luo Yang, Zhu, Lou Yijia *
The expression and activation of leukotriene C4 synthetase in rats with fulminant liver failure induced by D- galactosamine/lipopolysaccharide were enhanced. World Journal of Gastroenterology 2008; 14(7):2748-2756.
8. Icariin promotes the expression of 1α, PPARα and 1 during the differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta pharmacologica sinica 2007; 28( 10): 154 1- 1549.
9. Ding Ling; Liang Xingguang, Zhu, Lou Yijia *: Peroxisome proliferator-activated receptor α participates in the differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Cell Biology International 2007; 3 1: 1002- 1009.
10. Zhao Qingwei, Xin Huang, Yij-ia Lou*, Weber Nadine, Peter Proksch: the influence of ethanol extract of red bean. ) and Phaseolus lunatus L. on the phenotype of estrogen and progesterone receptors in MCF-7 /BOS cells. Phytotherapy Research 2007; 2 1:648-652.
1 1. Jiang Guojun, Li Tiejun, Qiu Yan, Chen Wansheng, Lou Yijia *: RNA interferes with HIF- 1α to inhibit foam cell formation in vitro. European journal of pharmacology. 2007; 562(3): 183- 190.
12., Zhu, Lou Yijia *: Icariin, a new anticancer drug, induced growth inhibition, G 1 arrest and mitochondrial transmembrane potential decrease in human prostate cancer PC-3 cells. European journal of pharmacology. 2007; 564:26-36.
13. Time dependence of peroxisome proliferator-activated receptor α inhibitor GW647 1 on the differentiation of mouse embryonic stem cells cardiomyocytes in vitro. Acta pharmacologica sinica 2007; 28(5):634-42.
14. Yao, Lou Yijia *: Steroid components in chloroform extracted from bee pollen of Brassica napus induced cell cycle arrest and apoptosis of human prostate cancer PC-3 cells. Phytotherapy Research 2007; 2 1( 1 1): 1087- 109 1.
15. Yang Shulong, Li, Yin Kong, Lou Yijia *: Sodium nitroprusside regulates the expression of LTC4 synthase mRNA in rats with hepatic ischemia-reperfusion injury through NF-kB signaling pathway. Pharmacology 2007; May, 80 (1): 1 1-20.
16. Yang Shulong, Hai, Li,
The increase of leukotriene C4 synthesis is accompanied by the increase of leukotriene C4 synthase expression and activity in rats with ischemia-reperfusion injury.
Journal of surgical research 2007; 140( 1):36-44.
17. Zhu * and Lou Yijia: Methodological study on directional differentiation of mouse embryonic stem cells into cardiomyocytes induced by icariin in vitro. China Journal of Pharmacy 2007; 42(9):29-33.
18。 Auml Yang Zhenning, Weber, Lou, Wang Zhiqing, Qiao Wolu, A. Kampk & ampouml Isopreneization enhances the cytotoxicity of apigenin and liquiritigenin in rat H4IIE liver cancer and C6 glioma cells. Food and Chemical Toxicology 2007; 45( 1): 1 19-24.
19. Shi Qiang, Lou Yijia *: Research progress in modification and activation of liver microsomes GST 1 by active nitrogen. China Journal of Pharmacology and Toxicology 2007; 2 1(4):297-300.
20. Yao, Lou Yijia *: Brassinolide, a phytosterol from Brassica napus pollen, induces apoptosis of human prostate cancer PC-3 cells. PHARMAZIE 200762(5):392-5.
2 1., Zhang Xiangnan, Qi Luo Yang, Lou Yijia *: The protective effect of icariin on amyloid β-protein-induced neurotoxicity of primary cultured rat neurons through estrogen-dependent pathway. Neuroscience. 2007; 145:9 1 1-922.
22. Hao, Ying, Weng Jia Lin, Zhou Changxin, Qiao, Lou Yijia *: The ethyl acetate fraction of Acorus calamus extract partially promoted the differentiation of adipocytes in 3T3-L 1 cells. Phytotherapy Research 2007; 2 1(6):562-564.
23. Sodium nitroprusside can reduce the production of leukotriene C4 by inhibiting the expression and activity of leukotriene C4 synthase in rats with hepatic ischemia-reperfusion injury. Biochemical pharmacology 2007; 73:724–735.
24. Lou Yijia * and Chen Zhe: New Opportunities in Cytology, Pharmacology and Toxicology. Journal of Zhejiang University (Medical Edition) 2007; 36(3):209-2 16.
25. Zhu, Zhang Xiangnan, Du Yue, Wang Zhiqiang, Lou Yijia: Icariin induces mouse embryonic stem cells to differentiate into nerve cells in vitro. Journal of Zhejiang University (Medical Edition) 2007; 36(3):2 17-223.
26. Zhang Xiangnan, Wang Zhiqiang, Wu Jiaying, Zhu, Lou Yijia *: Effect of Icariin on Apoptosis of Rat Primary Cultured Neurons (Medical Edition) 2007; 36(3):224-228.
27. Guo Meiyuan, Zhu, Du Yue, Lou Yijia *: Expression of microsomal phase II metabolic enzyme gene after mouse embryonic stem cells differentiate into hepatocytes. Journal of Zhejiang University (Medical Edition) 2007; 36(3):229-235.
28. Ma Kuifen, Zhang Xiangyi, Qi Luo Yang, Zhou Changxin, NINA Artanti, NOVIK Nurhidayat, LINCE Yarni, Lou Yijia *: The protective effect of triterpenoids on chemically damaged primary cultured rat hepatocytes. Journal of Zhejiang University (Medical Edition) 2007; 36(3):247-254.
29.Chiroyan Ma Kui-fen, Fang Fang Du Lou Yi Jia *: Leukotriene C4 Synthase Gene Expression and the Regulatory Role of Cyclosporine A in Concanavalin A-induced Liver Injury in Mice (Medical Edition) 2007; 36(3):24 1-246.
30. Ye, Zhu, Lou Yijia *: Effect of rat microsomal glutathione S- transferase 1 on tumor cytotoxicity induced by chlorambucil in vitro. Journal of Zhejiang University (Medical Edition) 2007; 36(3): 236-240.
3 1. Zhang Jie, Lou Yijia, Jose Hogmatens, Ann Van Sheppard: Screening drug metabolism by capillary electrophoresis. Electrophoresis 2006; 27(23):4827-35.
32. Bao Meihua, Lou Yijia *: isorhamnetin prevents oxidative low-density lipoprotein from damaging endothelial cells by activating p38MAPK.
European Journal of Pharmacology 2006; 547( 1-3):22-30;
33. Chen, Chen, Lou Yijia *: Further evidence that rat liver microsomal glutathione transferase 1 is not the target of S- nitrosation. Chemical-biological interaction in 2006; 162:228-236.
34.Meihua Bao, Yijia Lou*: Hippophae rhamnoides flavonoids protect endothelial cells (EA.hy926) from oxidative low density lipoprotein-induced damage by regulating the expression of LOX- 1 and eNOS. Journal of Cardiovascular Pharmacology 2006; 48( 1):834-84 1.
35. He Xudong, Wu Honghai, Lou Yijia *: Study on the lipid-regulating effect of atorvastatin combined with soybean isoflavone on experimental hyperlipidemia animals and its related mechanism. China Journal of Pharmacology and Toxicology 2006; 20(5):38 1-386.
36. Wo Yanbo, Zhu, Zhang Xiangnan, Lou Yijia *: Application of photoelectric imaging system in evaluating the directional differentiation of embryonic stem cells into cardiomyocytes in vitro. China Journal of Pharmacology and Toxicology 2006; 20(6):504-509.
37. Xiao Xingfeng, Wang Zhiqiang, Lou Yijia *: Immunomodulatory effect of icariin combined with panax notoginseng saponins on mice.
Chinese herbal medicine 2006; 37(6):233-236.
38. Wang Zhiqiang, Nadine Weber, Lou Yijia *, Peter Prokesch: Isopentenyl flavonoids as non-steroidal phytoestrogens and their related structure-activity relationships. Chemical Medicine 2006; 1(4):482-488.
39. Zhu, Lou Yijia *: Icariin mediates the expression of cardiac genes and the regulation of nitric oxide signaling pathway during the differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta pharmacologica sinica 2006; 27(3):3 1 1-20.
40.Zhang J, Ha PT, Lou Y, Hoogmartens J, Van Schepdael A*: Study on the effect of warfarin on cytochrome P450 3A4 activity by capillary electrophoresis fluorescence detection. J Chromatogr A. 2005 1082(2):235-9.
4 1. Zhang Jie, Pham Thi Thanh Ha, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael*: Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 2005; 39:6 12–6 17.
42. Zhao Qingwei, Li Bo, Ding Na Weber, Lou Yijia *, Prokesch: Estrogen-like effects of ethanol extracts from several leguminous plants in China on MCF-7 cells. European food research and technology in 2005; 22 1(6):828-833.
43. Ling Haiyun, Lou Yijia *: The total flavonoids of Elsholtzia reduced the infarct area during acute myocardial ischemia by inhibiting myocardial apoptosis in rats.
Ethnological pharmacology in 2005; 10 1: 169- 175.
44. Zhu, Qu Linhai, Zhang Xiangnan, Lou Yijia *: Icariin regulates cell cycle and p53 in the process of embryonic stem cells differentiating into cardiomyocytes. European journal of pharmacology. 2005; 5 14:99- 1 10.
45. Ling Haiyun, Lou Yijia *, Wu Honghai, Lou Hong Gang: The total flavonoids of Elsholtzia can reduce the infarct area and improve cardiac function in acute myocardial infarction by inhibiting myocardial cell apoptosis. Journal of Cardiology 2005; 60(3):295-30 1.
46. Ye Haiyong, Lou Yijia *: Estrogenic effects of two derivatives of icariin on human breast cancer 7 cells Plant Medicine 2005; 12:735-74 1.
47. Zhang Jie, Ye Zhiwei, Lou Yijia *: Metabolism of marfa Lun by glutathione S- transferase in rat liver microsomes. Chemical-biological interaction in 2005; 152: 10 1- 106;
48. Ye Haiyong, Lou Yijia *: Preparation of icariin derivatives and study on their estrogen-like effects. Journal of Zhejiang University (Medical Edition) 2005; 34(2) 13 1- 136.
49. Zhu, Lou Yijia *: Induction of directional differentiation of embryonic stem cells into cardiomyocytes by icariin, icariin and demethylicariin in vitro acta pharmacologica sinica 2005; 26(4):477-485.
50. Shi Qiang, Lou Yijia *: Microsomal glutathione transferase 1 No.
S- nitrosation in rats attacked by rat liver microsomes or endotoxin. Pharmacological research 2005; 5 1(4):303-3 10.
5 1. Liu Jian, Ye Haiyong, Lou Yijia *: Determination of urinary metabolites of icariin in rats and its estrogenic activity on MCF-7 cells. 2005 drug exhibition; 60(2): 120- 125.
52. Wang Zhiqiang, Lou Yijia *: The proliferation promoting effect of icariin and icariin.
Demethylicariin in MCF-7 cells. 2004; 504: 147- 153.
53. Liu Jian, Lou Yijia *: Determination of icariin and its metabolites in rat serum by capillary zone electrophoresis: Pharmacokinetics of icariin in rats after administration. Drug and biomedical analysis in 2004; 36:365-370.
54. Zhang Jie, Ye Zhiwei, Lou Yijia *: Metabolism of glutathione S- transferase in rat liver microsomes on chlorambucil. Chemical-biological interaction in 2004; 149:6 1-67;
55. Ling Haiyun, Lou Yijia *, Lou Hong Gang, Wu Honghai: Protective effect of total flavonoids of Elsholtzia on myocardial ischemia caused by coronary artery occlusion in dogs. Ethnological pharmacology in 2004; 94( 1); 10 1- 107.
56. Zheng, Lou Yijia: Pathological characteristics of immune injury of primary cultured rat hepatocytes and protective effect of glycyrrhizin on liver. Acta pharmacologica sinica 2003; 24(8):77 1-777.
57. Zhang Jie, Lou Yijia: Relationship between activation of microsomal glutathione S- transferase and metabolic behavior of chlorambucil. Pharmacological research 2003; 48: 623-630. 1. Pharmacotoxicology, the textbook of national higher medical planning, People's Health Publishing House, 2003, the first edition; The second edition in 2007 (the "Eleventh Five-Year" national key construction higher education planning textbook).
2. The National Higher Medical Education Planning Textbook "Pre-clinical Evaluation Course of New Drugs" (Pharmacology and Toxicology Evaluation Process), Zhejiang University Press, 2007 (it is a 2 1 century excellent course textbook and an applied undergraduate planning textbook).
Entries:
1. Zhou, editor-in-chief: Clinical Medical Planning Textbook of Ministry of Health, Pharmacology English Edition, People's Health Publishing House, 2007; First edition. Undertake two chapters of writing.
2. Pan Jiahu and Li Xuejun, editor-in-chief: Biochemistry and Molecular Pharmacology, a textbook for postgraduate planning, Fudan University Press, 2008 (a textbook for national key construction of higher education in the 11th Five-Year Plan).
Commitment: Chapter VI Microsomal Pharmacology; Chapter XVI Key Techniques of Biochemical and Molecular Pharmacology, Section III Stem Cell Research Techniques.
International and national conferences:
1. Zhang Xiangnan, Wu Jiaying,, Gerald Rimbach, Yijia Lou 1*: Centella asiatica attenuates the neurotoxicity of ceramide on primary cultured rat neurons and the activation of Caspase 3. Organization of nutritional genomics. Potsdam, September 2008,
Germany.
2. Ou Baihe, Lou Yijia, Yu Yongping *: Design and synthesis of icariin derivatives and their effects on the directional differentiation of embryonic stem cells. SINO- French Bioorganic and Medicinal Chemistry Seminar. 2007 10 month; P84。 Hangzhou, China.
3. Zhang Yandong, Yan Jieping, Ye, Yu Yongping *, Lou Yijia *: Solid-state synthesis and bioactivity evaluation of quinazoline derivatives. SINO- French Bioorganic and Medicinal Chemistry Seminar. 2007 10 month; ; P75。 Hangzhou, China.
4. Wu Jiaying, Yi Jialou *: Isopentyl Flavonoids, a non-steroidal phytoestrogen compound, and its structure-activity relationship. The 3rd International Symposium on Molecular Simulation and Information Technology Application, March 2007. Hangzhou, China.
5. Lou Yijia, Stem Cell Biology and Drug Discovery 1st Asian Union Seminar on Marine Natural Products and Medicinal Plants, AGU. 2007. Beijing, China. 20-27.
6. The Third National Symposium on the Application of Stem Cell Transplantation in Cardiovascular Diseases, with the special report "Stem Cell Biology and Drug Research" specially invited by the conference, June 2007, Hangzhou.
7. Lou Yijia *, Wu Yaodong: Anti-tumor and immunomodulatory activities of rape bee pollen polysaccharide protein complex. Oncology research (conference summary) 2006; 15( 10- 12):484.
8.,,,, Zhu, Lou Yijia *: Cytotoxic effects of icariin and vinblastine on pc-3 cell line. International Congress of Asian Toxicology Society. June 2006 Zhuhai, China.
9. Qi Luoyang, Zhu, Lou Yijia *: Relationship between activation of microsomal glutathione S- transferase and drug resistance of PC-3, K-562 and HepG2 cells. International Congress of Asian Toxicology Society. June 2006 Zhuhai, China.
10. Hai Feichen, Lou Yijia *: Overactivation of microsomal glutathione S- transferase 1 by acetaminophen is related to the formation of protein dimer in primary cultured rat hepatocytes. International Congress of Asian Toxicology Society. June 2006 Zhuhai, China.
1 1. Shi Qiang, Lou Yijia *: Overactivation of microsomal glutathione S- transferase 1 by acetaminophen is related to the formation of protein dimer, but not to the decrease of metabolite A. International Congress of Asian Toxicology Society. June 2006 Zhuhai, China.
12. Weber, W. W. & Ampaumltjen, R. Edrada, V. Wray, Y. Lou, z-q Wang and P. Proksch: Flavonoids in Red Bean-Composition and Antioxidant Activity, 54th Annual Meeting of the Society of Medicinal Plants. 2006; Helsinki. Finland.
13., Liang,, Zhu, Lou Yijia *:. Peroxisome proliferator-activated receptor α participates in cardiomyocyte differentiation of mouse embryonic stem cells in vitro. The 5th Asia-Pacific Conference on Cell Biology. October 2006. Beijing, China.
14. Kui, Luo, Zhu Danyan, Qu Linhai, Lou Yijia *: Cysteinyl leukotriene autocrine loop related to microsomal glutathione S- transferase-Ⅱ in rat hepatocytes. XI Satellite Conference of the 5th1World Pharmacology Congress, 2006, Xi 'an, China. 1 1 1- 1 12.
15., Zhu, Lou Yijia *: Cytotoxic effects of chlorambucil on rat microsomal glutathione S- transferase 1 on PC-3, K562, HepG2 and P388D 1 cell lines. The second Asia-Pacific forum on andrology in 2006. Shanghai, China.
16.,,, Zhu, Lou Yijia *: Anti-tumor activities of icariin, icariin and Morinda officinalis on PC-3 cell line. The second Asia-Pacific forum on andrology in 2006. Shanghai, China.
17. Liu Lulu, Zhu, Lou Yijia *: Pharmacokinetics of aristolochic acid I in Beagle dogs after a single oral dose of aristolochic acid or Guanxinsuhe capsule. The 2nd Young and Middle-aged Science and Technology Forum of China Toxicology Society. June 65438, 2007+10/October: 36
18. Ye, Chen, Zhu, Lou Yijia *: Study on the activation mechanism of primary cultured rat hepatocytes and human hepatocellular carcinoma cells HepG2 mGST 1 induced by excessive acetaminophen. The 2nd Young and Middle-aged Science and Technology Forum of China Toxicology Society. June 2007 5438+1October: 1 17 1. Application of icariin in inducing directional differentiation of embryonic stem cells in vitro.
Authorization announcement date: September, 2004 1 day, patent number: ZL 02160367.7; ;
2. Application of icariin or noricariin in preparing estrogen receptor modulators.
Announcement date of authorization: March 30, 2005, patent number: ZL 03129242.9; ;
3. Application of total flavonoids of Jigan Powder in preparing medicines for treating cardiovascular diseases.
Announcement date of authorization: February 5, 2006/kloc-0, patent number: ZL 02133759.4; ;
4. Composition containing simvastatin, pantethine and flavonoids and its use.
Patent number: ZL 02133759.4; ;
5. Application of total flavonoids of Jigan Powder in preparation of anti-ophthalmic drugs.
Publication number: CN 1757402, and publication date: April 200612;
6. An extract of effective parts of Acorus calamus and its use.
Publication number: CN 1973877, date of publication: June 6, 2007;
7. Application of Herba Epimedii total flavone and Panax Notoginseng total saponin composition (regulating the function of metabotropic glutamate receptor): CN101229210, published on July 30, 2008;
Use of 8.8- arylamino -3H- imidazole [4,5-g] quinazoline derivatives (application in preparation of anti-tumor drugs) Publication number: CN10120945, date of publication: February 2008.6438+03.
9. Use of quinazolimidazole compounds (compounds in combinatorial chemistry library induce embryonic stem cells to differentiate into cardiomyocytes): cn101254191,published on September 3, 2008;