2. 199 1 year-1995 studied in the Pharmacology Laboratory of Nagoya University, Japan;
3.65438+1June, 1997, obtained a doctorate in pharmacy from Hokuriku University, Japan;
4. 1995-1998 concurrently serves as a special researcher for foreigners in Nagoya University School of Medicine;
5. 1994-1998 concurrently serves as an associate professor in the Department of Pharmacology, West China University of Medical Sciences;
Social status:
He is currently the director of the National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine of Sichuan University. Expert in new drug evaluation of State Drug Administration, director of Sichuan Environmental Mutation Society, member of Toxicology Committee of Sichuan Preventive Medicine Association.
research direction
Pre-clinical safety evaluation of new drugs
Main research topics and achievements
1.2003-2006: Key project of National Natural Science Foundation-Safety Research of Aconitum Poisonous Traditional Chinese Medicine (sub-project leader), key project of National Natural Science Foundation;
2.2002-2003: The establishment of the technical platform for pre-clinical safety evaluation of new drugs (project leader) of the Ministry of Science and Technology (863 Program);
3. "Construction of National Safety Evaluation Center for Traditional Chinese Medicine" (project leader) in the Tenth Five-Year Plan of 2002-2003 "Modernization of Traditional Chinese Medicine and Industrialization of Science and Technology";
2002-2003: Rapid toxicity screening system for safety evaluation of traditional Chinese medicine in vitro (project leader);
2000-2003: The construction of Chinese medicine safety evaluation center (project leader) is the most important key project of the Ninth Five-Year Plan of the Ministry of Science and Technology.
1999-2000: preparation of aloe polysaccharide and its anti-tumor immune activity (project leader), a key scientific and technological project of Sichuan Science and Technology Department.
representative works
1.m., Sekido, T., I., Wang, L., Kitaichi, K., Itoh, A., Nabeshima, T. and Hasegawa, T.: Time-dependent effects of Klebsiella pneumoniae endotoxin on drug metabolizing enzyme activities in rat liver. J Pharm。 Pharmacology. , 50, 87 1-879 ( 1998) .(SCI)
2. M.,, I., Wang, L., Itoh, A., Naruhashi, K., Nabeshima, T., Asai, M. and Hasegawa, T.: Granulocyte colony stimulating factor enhances endotoxin-induced bile excretion reduction of cefoperazone in rats. Antimicrobial agent Chemical agent. , 42, 2 178-2 183 ( 1998).(SCI)
3. Hasegawa: The possible mechanism of carbapenem antibiotic panipenem reducing the concentration of valproic acid in rat plasma. Antimicrobial agent Special agent C. Heather. , 42, 3 136-3 140 ( 1998).).(SCI)
4.Kiyoyuki Kitaichi, Wang Li, Kenji Takaga, Mitsunori Iwase, Eiji Shibata, etc. Decreased clearance rate of antipyrine after endotoxin administration: evidence of nitric oxide in vivo. Antimicrobial agent Agent Chemothe 1999, 43:2697-270 1). (SCI)
5. Wang, L, Kiyoyuki Kitaichi, Cai, et al. Study on Macaulay Reversing Drug Resistance of Tumor Cells in Vitro and in Vivo. Clinical and Experimental Pharmacology, (2000) 27,587-593. ).(SCI)
6.Ando H, Nishio Y, Ito K, Nakao A, Wang L, Zhao, Kitaichi K, Takagi K, Hasegawa T. Effects of endotoxin on p- glycoprotein-mediated excretion of rhodamine-123 in rat bile and kidney. Chemical antibacterial agent 20065438+0dec; 45( 12):3462-7.(SCI)
7.Iwase M, Yokota M, Kitaichi K, Wang L, Takagi K, Nagasaka T, Izawa H, Hasegawa T. Changes of cardiac function and structure induced by endotoxin: the importance of platelet activating factor. Critically attack nursing medicine 200 1 March; 29(3):609- 17.(SCI)
8. Masayuki, Zhao,, etc. Endotoxin impairs the bile transport of sparfloxacin and its glucuronide in rats. European j pharmaceutical company, 200 1, 432:99- 105. (SCI)
9. Qing Wang Xing, Cai Li, Shao Hui, etc. Japanese journal of antibacterial, 200 1, 54: 49 ~ 52. (SCI)
10. Katsumi Ito, Li Wang, Hideyoshi Ando, et al. Pharmacodynamics induced by direct current: an animal experiment. Int J colorectal diseases, 200 1, 16: 326~330. (SCI)
1 1. Zhao Yinglan, Cai, and Bei Yiqing. P- glycoprotein may be involved in bile excretion of Grepat ofloxacin. Clinical and experimental pharmacy and physiotherapy, 2002, 29, 167- 172. (SCI)
12. Hideyuki Ando, Katsuji Ito, Li Wang, Kenji Hibu, etc. Effect of direct current on pharmacokinetics of adriamycin in rats. Anticancer drugs, 2002, 13:32 1-326. (SCI)
13. Wei, Li, Study on Hepatic Artery Embolization of Mitoxantrone with Carboxymethyl Starch Microspheres, Journal of Pharmacy,1998; 33 ( 10 ): 772~777
14. Du Junrong, Wang Li, Li Shuangqing, et al. Experimental study on prevention of atherosclerosis by aloe. Theory and clinic of traditional Chinese medicine. 1999, 15 ( 1): 27 ~ 28.
15. Du Junrong, Wang Li, Yang, et al. Protective effect of visrinone on mice with endotoxic shock. Bulletin of Chinese Pharmacological Society. 1999,16 (1): 20 ~ 21.
Protective effect of aloe polysaccharide extract on endotoxin-induced renal failure in rats. West China Journal of Pharmacy, 2000, 15 (4): 27 1 ~ 272.
Effects of aloe polysaccharide extract on cytokine secretion of spleen cells in normal and endotoxemic rats: Huaxi Pharmaceutical Journal 1999, 14: 2 17.
Effect of AP on cytokine secretion of spleen cells in normal and endotoxemia rats. Chinese Journal of Western Medicine, 1999, 14 (5 ~ 6): 346 ~ 348.
Effects of Aloe Polysaccharide from Cura? ao on Immune Function in Mice: Huaxi Pharmaceutical Journal 1999, 14:234.
20. Cen Xiaobo, Wang Ruishu, Wang Li. Preliminary study on characteristics and mechanism of zinc transmembrane transport in rat osteoblasts. Bulletin of Pharmacology of China, 200 1, 17 (1): 83.
2 1. Cen Xiaobo, Wang Ruishu, Wang Li. Role of metallothionein in zinc tolerance of rat osteoblasts. Health research, 200 1, 30( 1):67.
22. Cen Xiaobo, Wang Li. Application prospect of toxicology genomics in safety evaluation of compounds. Health research, 200 1, 30: 249.
23. Wang, Xiaobo, etc. Effects of aloe polysaccharide on lipid peroxide in serum and liver tissue of endotoxemia rats and normal aged rats. West China Journal of Pharmacy, 2002,17 (1): 21~ 22.