1.2 English name glutathione
1.3 Guladine alias is white barrier; Yi Shi An; Reduced glutathione; Glutathione; Naichian; Glutathione; Atomolan
1.4 classification of drugs in digestive system >: adjuvant drugs for liver diseases
1.5 dosage form 2%(5ml).
2. Injection (powder): 50 mg, 300 mg and 600 mg.
3. Tablets: 50 mg, 100 mg.
1.6 Pharmacology of Guladine Glutathione is a tripeptide composed of glutamic acid, cystine and glycine. It is an auxiliary group of glyceraldehyde dehydrogenase and a coenzyme of glyoxalase and triose phosphate dehydrogenase. It participates in the tricarboxylic acid cycle and sugar metabolism in the body, so that the human body can obtain high energy. Glutathione can activate sulfhydryl (SH) enzyme, coenzyme and other enzymes, thus promoting the metabolism of sugar, fat and protein, and also affecting the metabolic process of cells. It is an important substance for regulating metabolism in cells. In addition, glutathione exists in the body in two forms: glutathione (GSH) and oxidized glutathione (GSSG), and its active component is glutathione, which can participate in the redox process in the body. Glutathione can combine with peroxide and free radicals under the action of glutathione transferase, so as to destroy sulfhydryl groups through antioxidants, protect sulfhydryl-containing protein and sulfhydryl-containing enzymes in cell membranes from being destroyed, and also resist the damage of free radicals to important organs. Glutathione is widely distributed in animal and plant cells and is abundant in liver and lens. Now it can be produced by chemical synthesis or fermentation. Glutathione is the auxiliary group of glyceraldehyde phosphate dehydrogenase, and also the coenzyme of glyoxalase and triose phosphate dehydrogenase, which participates in the tricarboxylic acid cycle and sugar metabolism in the body and makes the human body get high energy. It can activate and protect various enzymes in the body, such as sulfhydryl (-SH) enzymes such as cholinesterase, so as to protect the body from harmful substances such as iodoacetic acid, mustard gas, free radicals (such as superoxide anion), heavy metals (such as mercury and lead) and epoxide, so as to promote the metabolism of sugar, fat and protein, and also affect the metabolic process of cells. It can promote the metabolism of eye tissue, inhibit the instability of protein sulfhydryl group in lens, and prevent the development of cataract and retinal diseases, so it can be used for keratitis and corneal trauma. For this disease, we should start to use this antioxidant regularly before entering old age, which can play a preventive role. At the same time, it also has a good effect on improving eyesight.
Pharmacokinetics of 1.7 Guladine Glutathione is a physiological factor with a wide range of physiological functions. It is synthesized in the cytoplasm, especially in the liver, and its metabolism is mainly in the liver and widely distributed in various organs of the body, which plays an important role in maintaining the biological function of cells. Animal pharmacological experiments showed that the plasma concentration of Guladine reached its peak 5 hours after intravenous injection, and it could be detected in liver, kidney, muscle and other tissues 1 hour after injection, and a small amount was found in brain, with a half-life of 24 hours. It is mainly excreted from the kidney and cleared by the kidney in two ways: direct filtration of glomerulus and non-filtration mechanism of γ -glutamine transpeptidase reaction.
Indications 1.8 guladine 1. It can be used for treating various liver diseases, especially alcoholic liver diseases and drug-induced liver diseases (including anticancer drugs, antituberculosis drugs, psychotropic drugs, antidepressants, acetaminophen and traditional Chinese medicines). ), it can also improve symptoms and signs and restore liver function for infectious liver diseases-chronic active hepatitis B and hepatitis C.
2. Used to rescue poisoning caused by heavy metals and organic solvents.
3. Prevention and treatment of radiation injury, leukopenia and bone marrow inflammation caused by radiation.
4. Used for facial pigmentation, sweat spots and pigmentation caused by various reasons.
5. Eye drops can be used for early senile cataract, corneal ulcer, corneal epithelial exfoliation, keratitis, etc.
Contraindications 1.9 Guladine is prohibited for those who are allergic to Guladine.
1. 10 Note 1. Do not mix with vitamin B 12, vitamin K3, calcium pantothenate, orotic acid, antihistamine preparation, sulfanilamide preparation and tetracycline preparation during injection.
2. Do not use topical eye drops containing sulfonamides and tetracyclines.
3. Eye drops should be used within 1 month after dissolution.
Adverse reactions of 1. 1 1 guladine 1 Rash, stomachache, nausea and vomiting may occur after taking the medicine. And there may be slight pain at the injection site.
2. A few patients may have itching sensation, * * sensation, eye congestion, transient blurred vision and other symptoms after taking Guladine eye drops, and disappear after stopping taking them.
1. 12 usage and dosage of guladine 1. Dissolve with the attached 2ml vitamin C injection, and then use Guladine injection. 300 ~ 600 mg per day, 600 ~ 1 200 mg per day for severe cases, 1 ~ 2 times per day.
2. Intravenous injection: the usage and dosage are the same as intramuscular injection.
3. Oral: 50 ~ 100 mg each time, 1 ~ 3 times a day. Can be appropriately increased or decreased according to age and symptoms. Ophthalmic administration: dissolve 100mg glutathione in 5ml solution or use 2% eye drops, 1 ~ 2 drops each time, 3 ~ 5 times a day.
1. 13 drug interaction 1. Do not mix with vitamin B 12, vitamin K3, calcium pantothenate, orotic acid, antihistamines, sulfonamides and tetracyclines during injection.
2. Glutathione can reduce the toxic and side effects of mitomycin.
1. 14 expert comments
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