Acetylsalicylic acid’s common name is aspirin.
Aspirin, also known as acetylsalicylic acid, is an organic compound with the chemical formula C9H8O4. It is a white crystalline powder, soluble in ethanol, ether, and slightly soluble in water. It is mainly used as a solution. Thermal analgesia, non-steroidal anti-inflammatory drugs, and anti-platelet aggregation drugs have been used clinically for nearly a hundred years;
proven to relieve mild or moderate pain, such as toothache, headache, neuralgia, and muscle aches. It is effective in treating fever and dysmenorrhea. It is also used to reduce fever in colds, flu and other febrile diseases, and to treat rheumatic pain. It can prevent thrombosis and is clinically used to prevent transient ischemic attacks, myocardial infarction, artificial heart valves and venous fistulas or Development of blood clots after other surgeries.
As early as 1853 in Shire, Frederic Gérard (Gerhardt) synthesized acetylsalicylic acid (acetylated salicylic acid) from salicylic acid and acetic anhydride, but failed. attract people's attention.
In 1897, German chemist Felix Hofmann synthesized it again and treated his father's rheumatoid arthritis with excellent results. In 1897, Bayer in Germany synthesized the main substance of aspirin for the first time.
Aspirin was launched in 1898, and it was discovered that it also had anti-platelet aggregation effects, which aroused great interest again. Aspirin and other salicylic acid derivatives are melted and esterified with hydroxyl-containing polymers such as polyvinyl alcohol and cellulose acetate to polymerize them. The resulting product has anti-inflammatory, antipyretic and analgesic properties longer than free aspirin. effect.
By 1899, Bayer used aspirin as its trademark and sold the drug worldwide.
As of 2015, aspirin has been used for a hundred years and has become one of the three classic drugs in the history of medicine. It is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world. It is also used as a comparison and evaluation of standard formulations of other drugs.
It has an anti-thrombotic effect in the body. It can inhibit the release reaction of platelets and inhibit the aggregation of platelets, which is related to the reduction of TXA2 production. Clinically used to prevent the onset of cardiovascular and cerebrovascular diseases.