1) Madrid registration requires an application basis, but EU registration does not; 2) In terms of time, if everything goes well, it will take longer to complete the designated EU registration through Madrid than to apply for registration directly through the EU. The application for designation of the EU through Madrid is submitted to the International Bureau through the National Trademark Office of my country, and then submitted to the European Union Internal Market Coordination Office by the International Bureau. Finally, the Internal Market Coordination Office distributes it to the EU member states for review; the EU application is directly submitted to the European Union. It is submitted to the European Union Market for Harmonization and then distributed to each EU member state for review. Madrid registration is generally reviewed within 12 to 18 months after each member state receives the application. EU registration is generally completed within 12 to 18 months. Since the application for registration in Madrid to designate the EU needs to be forwarded through many layers in the early stage before it can reach each EU member state, there is a gap of about half a year in the total time. 3) In terms of registration certificate, after successful registration through the Madrid-designated EU, the International Bureau will not issue the corresponding registration certificate; and after direct registration through the EU, the EU Internal Market Coordination Office will issue a registration certificate as a certificate of rights for the trademark. 4) In terms of fees, the cost of designating the EU through Madrid is lower than applying directly through the EU. 5) As far as the application procedure is concerned, the application for registration in Madrid to designate the EU needs to go through layers of transfers in the early stage before it can reach each EU member state.