brand name: URINORM Tab

English name: Benzbromarone

Chinese name: benzbromarone tablets

manufacturer: torii Jipin

ユリー. Mg

structure

molecular formula

C17H12Br2O3 (424.8)

common name

ベンズブマロンンンンンンンンンンン

This product is soluble in N, n- dimethylformamide, easily soluble in acetone, slightly soluble in ethanol (99.5), and insoluble in water.

this product is melted into dilute sodium hydroxide test solution.

distribution coefficient

1. briton-roinson wide-area bffer/clocm ph2, 4, 6, 7.4, 8: , ph2: .8, ph2: .64

2..1] nooh/chloroform = 146.3 (ph13) <

(1) Pharmacological action

Because this drug was administered to gout patients, it showed a decrease and an increase in serum uric acid level in uric acid clearance, and creatinine clearance hardly changed. Although it is observed that the decrease of uric acid pool is similar to the decrease of serum uric acid value, the daily output of uric acid is not surprising. Therefore, this drug is considered to selectively promote the excretion of uric acid in urine.

(2) Mechanism of action

1) This drug was given to healthy adults, and the effect of the current drug on urinary capillaries was examined. As a benzoyl phthalate in urine excretion and blood concentration, this preparation did not play a small role in these urine excretion and blood concentration, because it was considered to only inhibit the reabsorption of uric acid in renal tubules, unlike propionic acid.

2) Uric acid filtered in glomerulus is reabsorbed by uric acid transporter (urat1) on the lumen side of proximal renal tubule.

6- hydroxyls are the main metabolites of benzbromarone and benzbromelain, which inhibit the absorption of uric acid through urat1 (in vitro).

that is to say, benzoben Company and 6- hydroxyls are thought to reduce the blood uric acid value by inhibiting the reabsorption of uric acid and promoting the urinary excretion of uric acid through urat1.

indications

improvement of hyperuricemia under the following conditions:

gout and hyperuricemia and hypertension

usage and dosage

1. gout

adults: take one and a half tablets or one tablet (25 mg or 5 mg of benzonamuron) orally at a time, and one tablet is 1-3 times daily as the subsequent maintenance amount (5-15 mg). In addition, age, it is appropriate to increase or decrease depending on the symptoms.

2. Hyperuricemia and hypertension

Adults: once, once or three times a day (5 ~15 mg of benzobrunron) orally. In addition, age, it is appropriate to increase or decrease depending on the symptoms.

packaging

PTP packages 1 ingots (1 ingots× 1), 5 ingots (1 ingots× 5), 7 ingots (14 ingots× 5) and 1, ingots (1 ingots× 1)

1, ingots.

attachment to the complete manual: http://www.info.pmda.go.jp/go/pack/39492F2114_1_6/.