Pregnancy screening
Ordinary pregnant women need to build a card after pregnancy. When establishing a card for early pregnancy, the doctor will open a test sheet, one of which is hepatitis B test. If it is negative, there is no need for further intervention. If it is positive, is it necessary to test HBV? DNA level. Serum HBV in pregnant women? DNA level is the main risk factor for mother-to-child transmission of HBV. The DNA level is less than 6 logarithms. When hepatitis B vaccine is combined with hepatitis B immunoglobulin (HBIG), the probability of mother-to-child transmission of HBV is very low when the replication amount is /ml.
Parents have hepatitis B, how can the baby avoid infection?
antiviral therapy
In recent years, the main guidelines for the prevention and treatment of chronic hepatitis B at home and abroad recommend the mother-to-child blocking measures of antiviral treatment for mothers with high viral load. On the basis of combined immunization with neonatal hepatitis B vaccine and HBIG, adding antiviral drugs to pregnant women with high viral load in the third trimester of pregnancy can further reduce the mother-to-child transmission of hepatitis B. 。
The most commonly used antiviral drugs are tenofovir disoproxil fumarate (TDF) and telbivudine (LdT), both of which are drugs for treating pregnancy and can be used safely. When to start using: Start using in the third trimester, generally speaking, start using after 28 weeks in the first trimester. However, when to start can be decided by the infectious doctor.
What medicine do you need? It must be used when the mother's serum HBV DNA level is greater than the logarithm of 6. However, some studies show that HBV? A DNA level of more than 5 logarithms may also increase some infectivity, or it may be used without consulting an infection expert.
Infant immunity
At present, the inoculation scheme of 0, 1 and 6 months is generally adopted, and each time 10-20 g (genetic engineering vaccine). High-risk groups can increase the dose appropriately, and the anti -HBs positive conversion rate can reach above 90%. Newborns of mothers infected with chronic hepatitis B virus are injected with hepatitis B immunoglobulin (HBIG) 100-200 u immediately after birth, and vaccinated with HBV vaccine (10 microgram, different from immunoglobulin) within 3 days, preferably within 24 hours, and at 10789 months and 60789 months after birth. Parents have hepatitis B, how can the baby avoid infection?
breast feeding
Newborns who are injected with hepatitis B immunoglobulin and vaccinated with hepatitis B vaccine within 0/2 hours after birth can breastfeed. Breast milk inevitably contains HBsAg and HBV-DNA, but in infancy, immune proteins in breast milk are irreplaceable disease prevention substances, such as lactoferrin, which has been proved to inhibit and kill many viruses. Therefore, even if the pregnant woman is a third child, breastfeeding will not increase the risk of infection after the newborn is vaccinated with hepatitis B vaccine.
What about her husband's hepatitis B?
What about my husband's hepatitis B? If one sexual partner is infected with HBV, the first step is to determine whether the other sexual partner has been vaccinated. If you are not vaccinated, the probability of contracting HBV from your spouse (heterosexual partner) through normal sexual behavior is 25%. If one spouse is infected with the virus that the other spouse is not infected with, the uninfected spouse should quantitatively detect HBsAb before pregnancy and be vaccinated with standard hepatitis B vaccine instead of hepatitis B immunoglobulin. Sexual intercourse and virus contact should be avoided during vaccination, and antibody titer should be checked again after vaccination to ensure normal immune function. Once the vaccination is successful, the couple can have spontaneous behavior.
The above is the basic scientific knowledge of preventing mother-to-child transmission of hepatitis B, but in practice, more detailed gender management is needed to truly realize zero mother-to-child transmission of hepatitis B. On this World Hepatitis B Day, I wish your baby health. Through the scientific understanding of mother-to-child transmission of hepatitis B, infants should not suffer from hepatitis B.