Research field and direction: Study on the function and pathogenesis of neurodegenerative diseases: 1. Study on the pathogenesis of hereditary spastic paraplegia gene SLC33A 1 by using gene knock-in mouse model, Shandong Outstanding Young and Middle-aged Scientists Research Award Fund, 2012.7-2014.122. Further research on the function of genetic spastic paraplegia pathogenic gene SLC33A 1 by using gene knock-in mouse model has received special support from China Postdoctoral Science Fund. 2011.1-2012.123. Effect of gene missense mutation on axonal transport in hereditary spastic paraplegia SLC33A 1, 201/. Study on the mechanism of missense mutation of SLC33A 1 gene in hereditary spastic paraplegia from the perspective of axonal transport, National Natural Science Foundation of China, Youth Science Fund, 201.1-201./kloc-0. Study on pathogenesis of missense mutation of genetic spastic paraplegia gene SLC33A 1, China Postdoctoral Science Foundation, 2009.1-201.126. Study on pathogenic mechanism of HSP gene SLC33A 1 missense mutation, Shandong Postdoctoral Innovation Project Special Fund, 2009.1-201.127. Study on the pathogenic mechanism of SLC33a 1 gene missense mutation, special project of talent introduction and training of independent innovation fund of Shandong University, 2009.2009. 16438+0.