Number of toxicity test data reported in literature and periodicals. Toxicity type test method Subjects used dose toxic effect 1, acute toxicity, 420 mg/kg/ 6W 1 orally. Endocrine toxicity-diabetes insipidus (kidney or central nervous system) II. Biochemical toxicity-affects the acute toxicity of cyclic nucleotide 2. Oral human 10 mg/kg 1. Skin and collateral toxicity-dermatitis (after systemic contact) 2. Toxicity of skin and accessories-affecting nails 3. Immune system toxicity-allergic rhinitis, serum sickness, acute toxicity, 68 mg/kg/8D 1. Kidney, ureter and bladder toxicity-increased urine volume, 2. Toxicity of kidney, ureter and bladder-changes of urine composition, 4. Acute toxicity, the detailed effect of oral administration of rats >: 6750 mg/kg did not report other values except lethal dose. 5. The detailed effect of acute toxic intraperitoneal injection in rats is 358 mg/kg. No other values were reported except lethal dose. 6. The detailed effect of acute toxic subcutaneous injection >: 2 mg/kg in rats has not been reported except the lethal dose. The detailed effect of acute toxic intravenous injection in rats was 65438 0.46 mg/kg. No other values were reported except lethal dose. The acute toxicity of oral administration in mice was 4mg/kg. No other values were reported except the lethal dose. Nine mice with acute poisoning were intraperitoneally injected with 454 mg/kg. The detailed action did not report other values except the lethal dose. 10 The detailed effect of subcutaneous injection of 2500mg/kg in mice with acute toxicity was not reported 1 1 The detailed effect of intravenous injection of 79mg/kg in mice was not reported/The mutant toxicity of human lymphocytes was 3750μ g/kg, and the reproductive toxicity of adult female rats was 240mg. The oral reproductive toxicity dose of rats is 5 mg/kg. Female pregnancy 1-22 days later 1. Reproductive toxicity-abnormal development of skull and face (including nose/tongue) II. Reproductive toxicity-abnormal development of skin and skin accessories. Reproductive toxicity-other changes/The reproductive toxicity of oral administration of 5 mg/kg in rats and oral administration of 1-22 days in female rats.