2. Patients with tuberculosis, diabetes and arteriosclerosis should not be used with caution.
3. The effect of this drug on children During the use of this drug, the secretion of growth hormone is inhibited, so children should be cautious when using it.
4. The influence of drugs on pregnancy is not suitable for pregnant women. The US Food and Drug Administration (FDA) has classified the pregnancy safety of this drug as Class C. ..
5. The effect of drugs on lactation is not clear whether this drug can be secreted into breast milk.
6. Before and after medication and during medication, check or monitor the reduction or sudden withdrawal of drugs, monitor cardiac function and observe myocardial changes at any time.
1. Allergic reactions A few patients may have allergic reactions, including fever, rash, angioneurotic edema, and occasionally anaphylactic shock. These reactions are more likely to occur in patients with hypogonadism and hypoadrenocorticism, especially during intravenous injection. Therefore, the patients suspected of hypoadrenocortical function should take dexamethasone orally (1mg/ day) for ACTH test to avoid serious reaction.
2. Long-term high-dose use of this product in cardiovascular system may lead to hypertension, cardiac enlargement and enhanced left ventricular compensatory function.
3. Headache may appear in nervous system, and it may also induce mental disorder, emotional instability, euphoria, insomnia, depression and personality change, which may be due to the increase of cortisone secretion, but it may also be due to the direct effect of the drug.
4. Metabolic/endocrine system can produce the related reaction of glucocorticoid and mineralocorticoid increase (iatrogenic Cushing syndrome, obvious water and sodium retention and considerable potassium loss). Other reports are as follows: adrenal hemorrhage, suppression of thyroid hormone secretion, decreased response of growth hormone to hypoglycemia (possibly leading to hyperglycemia), and increased androgen secretion (leading to acne and hirsutism). It is reported that some women appear masculine after taking drugs.
5. Blood will lead to a significant increase in white blood cells.
6. Skin can induce skin pigmentation, and long-term use of synthetic ACTH may induce melanosis.
7. Reports of other bilateral cataracts.
1. This product should not be compatible with neutral and alkaline injections, such as sodium chloride, sodium glutamate and aminophylline, to avoid turbidity.
2. Sudden withdrawal of drugs can cause pituitary dysfunction, and the withdrawal should be gradually reduced and then stopped.
3. Long-term use of this drug will weaken the stress response ability of pituitary-adrenal axis.
This medicine can enhance the blood coagulation function of the body. If it must be combined with anticoagulants, the dosage of the latter should be increased as appropriate.
5. This drug can raise blood sugar, and the dosage of the latter should be increased when it is used together with hypoglycemic drugs.
6. When the thyroid function is low, the effect of this medicine will be enhanced.
7. Attention should be paid to the occurrence of allergic or hypotensive reactions when conducting diagnostic excitement tests on patients with suspected hypoadrenocortical function.
adult
Conventional dose
intramuscular injection
1. Short-acting preparation: 25U once, twice a day. Intramuscular injections are short-lived and need to be injected several times a day. It is rarely used now.
2. Long-acting preparation: 40-80U once,/kloc-0 once every 24-72 hours, and the dosage should be gradually reduced as soon as possible until the minimum amount needed to control symptoms.
3. Treatment of acute and severe patients with multiple scleroderma: 80- 120U a day, administered in batches for 3 weeks.
Intravenous infusion
1. Used to diagnose the reserve function of pituitary-adrenal axis: 20-25U each time, lasting for 8 hours, to maximize the excitement of adrenal cortex.
2. Treatment of acute severe multiple scleroderma: 12.5-25U once, dissolved in 500ml of 5% glucose injection, drip for 8 hours,/kloc-0 once a day.
[Refer to foreign usage and dosage]
adult
Conventional dose
intramuscular injection
1. Diseases requiring glucocorticoid treatment: 10-20U once, 4 times a day.
2. Rapid detection of adrenal function: A single dose of 25U was given, and the concentration of corticosteroids was detected before and 45 minutes after administration.
3. Treatment of acute gout attack: 40-80U a day, and gradually decrease after 2-3 days. Colchicine 0.6mg should be given 2-3 times a day during and within 7 days after treatment to prevent the recurrence of acute gout.
4. Control the acute attack of multiple sclerosis: 80- 120U per day for 2-3 weeks, and then gradually reduce it within a few weeks.
5. Improve the clinical symptoms of patients with myasthenia gravis: 100U every day, for a total of 10 days.
6. Treatment of nasal polyps: 80U per day for 5 consecutive days, and then gradually reduce the amount by 10U per day.
Intravenous administration
1. Diagnosis of adrenal insufficiency: The usual dose is a single dose 10-25U, diluted in 500 ml of 5% glucose injection and dripped for 8 hours.
2. Adrenal function test: The drug was continuously infused intravenously, and 40U was administered every 12 hours within 48 hours. This scheme is not often used.
3. Treatment of acute gout attack: 40-80U of this product is diluted in 250-500ml normal saline for intravenous drip. Colchicine 0.6mg should be given 2-3 times a day during and within 7 days after treatment to prevent the recurrence of acute gout.
To control the acute exacerbation of multiple sclerosis by mixed administration: 80U daily, diluted and instilled in the middle vein for at least 8 hours for 3 consecutive days; Then intramuscular injection of 40U, once, twice a day for 7 days. Then gradually reduce it to stop taking medicine in the next 3-4 weeks. This is another commonly used drug administration method to control the acute deterioration of multiple sclerosis.
Subcutaneous administration requires glucocorticoid treatment: intramuscular injection.
Partial dose of liver dysfunction
Liver cirrhosis needs to be reduced, but there is no recommended plan.
Doses of other diseases
When thyroid function is low, the curative effect of this drug will be enhanced, so it is necessary to reduce the dose of this drug, but there is no recommended scheme at present.
children
Conventional dose
Intramuscular injection of infantile spasms (West syndrome): There are various treatment schemes: (1) 5-8U/kg per day, administered twice, *** 14-2 1 day, and then gradually reduced. (2) 80- 100U daily. After the spasm stops, reduce it to the maintenance dose for about 6 months to avoid recurrence. (3) 20U per day for 2 weeks, and then decreased gradually for 7 days. (4) 40U daily for 2 weeks, then 80U each time, every 2 days 1 time, at least 3 months. (5) 20-40U daily for 6 weeks, and then gradually reduced. (6) 40- 160U daily for 3 weeks; 20-80U per day for 2 weeks; And then gradually decrease.
Corticotropin for injection (1)25U. (2)50U .
Corticotropin 16% gelatin injection (1) 1ml:40U. (2) 1 ml: 80U.
Corticotropin zinc hydroxide suspension 1 ml: 40 units.
Storage method: 2-8℃, dark and cold storage.
(1) is allergic to pig protein. (2) postoperative patients. (3) osteoporosis. (4) Systemic fungal infection. (5) Patients with ocular herpes simplex. (6) Patients with peptic ulcer. (7) Patients with hypertension. (8) Patients with congestive heart failure.
Product Name ApprovalNo./RegistrationNo. Specification dosage form manufacturing enterprise Adrenocorticotropin National Medicine Standard H3 1022942 Raw material Shanghai First Biochemical Pharmaceutical Co., Ltd. Adrenocorticotropin National Medicine Standard H31022125 Unit Injection (Freeze-dried) Shanghai First Biochemical Pharmaceutical Co., Ltd. Adrenocorticotropin National Medicine Standard H/.