Choosing a nickname for a novel is a creative process that requires consideration of the novel's theme, characters, plot, and target readers. Here are some suggestions that may help:

1. Keep the core theme or plot of the novel and make only minor changes in grammar or wording. For example, change "One Hundred Years of Solitude" to "One Hundred Years of Not Being Alone" or "One Hundred Years of Solitude".

2. Make changes based on the name of the main character or protagonist. For example, "The Little Prince" was changed to "The Little Princess", "The Little Kid", etc.

3. Make changes according to the background of the novel or the background of the times. For example, change "Good Man from Tang Dynasty" to "Good Man from Song Dynasty", "Good Man from Qing Dynasty", etc.

4. Make changes to suit the style or genre of the novel. For example, change "Three-Body" to "Four-Body", "Five-Body", etc.

5. Choose a completely different name that has no connection with the content of the novel but is attractive and meaningful. For example, "Harry Potter" was changed to "The Sorcerer's Hat."

Please note that when changing the name of the novel, you need to pay attention to trademark law to ensure that the name does not conflict with existing trademarks or copyrights. In addition, you also need to consider the receptivity of your target readers and choose a name that will attract them and arouse their interest.