Drug name: CLARITYNE
Common name: Loratadine tablets
Trade name: CLARITYNE
English name :Loratadine Tablets
Chinese Pinyin: Lü Lei Ta Ding Pian
Main ingredients: The main ingredients and their chemical names of this product are: Loratadine, 4-(8-chloro- 5,6-Dihydro-11H-benzocyclohepto[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester.
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Drug information
Appearance: This product is a white tablet, containing 10 mg of micronized loratadine. Other inactive ingredients include corn starch, lactose, and magnesium stearate.
Pharmacology, Toxicology and Pharmacology Loratadine is an oral, highly effective, long-lasting tricyclic antihistamine. It has a rapid onset of action, strong effect, and selective antagonism to peripheral H1 receptors.
In experiments with mice, rats, and monkeys, neither loratadine nor its metabolites passed the blood-brain barrier, and studies with guinea pigs showed that compared with H1 receptors in the central nervous system , this product has a more selective binding effect on peripheral H1 receptors. This product has no obvious anticholinergic and central nervous system inhibitory effects.
Toxicology: Animal tests showed no obvious teratogenic effects.
Pharmacological effects: This product is a highly effective, long-lasting tricyclic antihistamine and a selective peripheral H1 receptor antagonist. Can relieve various symptoms caused by allergic reactions.
Pharmacokinetics: Rapid absorption after oral administration on an empty stomach. It takes effect 1 to 3 hours after taking it, reaches the maximum effect in 8 to 12 hours, and lasts for more than 24 hours. Food can delay the drug peak time by about 1 hour and increase AUC. In normal adults, the T1/2 of loratadine is 28 (8.8-92) hours. 80% appears in urine and feces as metabolites. In patients with chronic renal failure (creatinine clearance ≤30 ml/min), the AUC and plasma concentration of the drug increase by approximately 73%, while the AUC of its metabolites increase by approximately 120%. In patients with chronic alcoholic liver disease, the AUC and peak concentration of loratadine are twice that of normal people. The T1/2 of loratadine and its metabolites are 24 and 37 hours respectively, which can be extended with the severity of the liver disease. The protein binding rates of loratadine and its metabolites are 97% and 73% to 77% respectively. This product and its metabolites cannot easily penetrate the blood-brain barrier and mainly act at peripheral H1 receptor sites.
Indications are for the relief of symptoms related to allergic rhinitis, such as sneezing, runny nose, nasal itching, nasal congestion, and eye itching and burning sensation. Rapid relief of nasal and ocular symptoms and signs after oral administration. This product is also suitable for relieving the symptoms and signs of chronic urticaria, itchy skin diseases and other allergic skin diseases.
Usage and dosage: Take orally.
Adults and children over 12 years old: 1 tablet (10mg) once a day.
Children aged 2-12 years old:
Weight >30 kg: 1 tablet (10 mg) once a day.
Weight <30 kg: Take half a tablet (5 mg) once a day.
Adverse Reactions: At the recommended dose of 10 mg per day, this product has no obvious sedative effect. Common adverse reactions include fatigue, headache, drowsiness, dry mouth, gastrointestinal discomfort including nausea, gastritis, and rash. Rare adverse reactions include hair loss, allergic reactions, abnormal liver function, tachycardia and palpitations.
It is contraindicated for patients who are allergic to the ingredients in this product or have special constitutions.
Notes 1. Patients with severe liver dysfunction should use it under the guidance of a doctor. 2． Use with caution in pregnant and lactating women. 3． The use of this product should be discontinued about 48 hours before the skin test, as antihistamines can prevent or reduce the occurrence of a positive reaction in the skin test. 4． It is forbidden when the properties of this product change. 5. Children must use under adult supervision. 6. Please keep this medicine out of the reach of children.
Interaction 1. Simultaneous use of ketoconazole, macrolide antibiotics, cimetidine, theophylline and other drugs will increase the concentration of loratadine in plasma and should be used with caution.
Other drugs known to inhibit hepatic metabolism should be used with caution until interactions with loratadine are not clear. 2． If you are taking other medicines, please consult your physician or pharmacist before using this product.
Pregnant women and lactating women should use this medication with caution. Breastfeeding should be stopped during the medication period.
Pediatric Medication The safety of this product in children under 12 years of age has not been determined.
When the elderly use the drug with mild to moderate impairment of liver and kidney function, it will not have a significant impact on the metabolism and excretion of this drug, so the dosage for elderly patients is the same as for adults.
In case of drug overdose or poisoning, vomiting can be induced if the patient is awake. Gastric lavage with normal saline can be performed, and activated charcoal can be given to absorb drugs. Salt laxatives (sodium sulfate) may also be considered to prevent intestinal absorption of the drug. Hemodialysis cannot eliminate this product, and it is not clear whether peritoneal dialysis can eliminate this product.