In 1899, Albert Alexander Hyde, a Christian from Kansas, USA, used peppermint and petroleum jelly to make an ointment and established the Mentholatum Company. In the earliest times, Mentholatum was used to treat colds.

In 1920, American architect William Merrell Vories went to Omi Hachiman in Shiga Prefecture, Japan, and obtained the agent authorization of Mentholatum to sell Mentholatum in Japan. Soon the Omi Brothers Company was established to support public welfare undertakings in Shiga Prefecture and promote Christianity through profits from the production and sale of medicines. After the Second World War, Japanese artist Shichiro Imaki used the American child star Shirley Temple as a model to design the Mentholatum Little Nurse trademark for the Omi brothers. The advertisements in Taiwan had a signature advertising song: "Little Nurse" , little nurse, face Sulidam...".

In December 1974, Omi Brothers filed for bankruptcy protection due to poor management, and returned the Japanese agency rights of Mentholatum to the American Mentholatum Company; the agency was later awarded to Japan's Rohto in August 1975 Pharmaceuticals. When the Omi brothers returned their agency rights, they also sold the Little Nurse trademark to Mentholatum.

In 1988, Rohto Pharmaceuticals purchased Mentholatum Company as its wholly-owned subsidiary. In other words, Mentholatum belongs to Rohto Pharmaceuticals 100%. After the bankruptcy, Omi Brothers was reborn with financial support from Taiho Pharmaceutical Industry (a subsidiary of Otsuka Pharmaceutical) and launched mint Vaseline ointment again.