According to molecular classification, breast cancer can be divided into luminol type, HER-2(+) type and basal type. The prognosis of triple negative breast cancer has little to do with tumor size and lymph node status, and the recurrence is relatively fast. The peak of recurrence is 1-3 years, and the incidence of brain metastasis is high.
The 5-year survival rate of this type of breast cancer is less than 80%, which is more common in young premenopausal patients. The probability of visceral metastasis and brain metastasis is high, the histopathological grade is poor, mostly grade 3, and the proportion of cell proliferation is high.
Most of them were accompanied by p53 mutation, c-kit, p53 and EGFR were positive, and basal cell markers CK5/6 and CK 17 were also positive. Tumors are highly invasive, and are relatively prone to local recurrence and distant metastasis. Breast cancer associated with basal cell-like breast cancer and BRCA 1 gene mutation has many similar characteristics.
Extended data:
Lifestyles related to breast cancer:
1, staying up late: Staying up late will disrupt the body's biological clock, make the brain hormone secretion disorder, and increase the risk of breast cancer.
2, mental stimulation: mental stimulation can lead to endocrine disorders and promote the occurrence of breast cancer. The risk of breast cancer in women who have experienced mental trauma can be increased to 2-3 times that of the general population.
3, smoking: smoking is the cause of breast cancer. The incidence of breast cancer in smokers is 2/3 higher than that in the general population. Women who start smoking in adolescence will have a 70% increased risk of breast cancer.
4, induced abortion: abortion leads to a sudden change in the level of estrogen in the body, making the development of breast epithelium abnormal, and repeated abortion stimulation can become the cause of breast cancer.
5, tight underwear: wearing tight underwear is easy to cause breast cancer, tight underwear and tight bra will affect lymphatic reflux and increase the risk of breast cancer.
6, hormonal drugs: taking estrogen drugs in order to make breasts full or delay menopause will lead to endocrine disorders and increase the risk of breast cancer. Therefore, the use of estrogen drugs should be in accordance with the doctor's advice and must not be taken in large doses for a long time.
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